TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature Review
Background. The syndrome of tubulointerstitial nephritis and uveitis (TINU) is a rare oculorenal condition, mainly seen in children and women. The underlying cause of this disease is unknown. Case Presentation. We report a 24-year-old male without any past medical history, diagnosed with bilateral u...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2024/3909755 |
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| _version_ | 1832548371607322624 |
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| author | Juan Montejo-Hernández Jorge Rico-Fontalvo Jose Cabrales Shuchi Anand María Cristina Martínez-Ávila Claudia Duran-Merino Luis Arias-Restrepo Camilo Andrés Gómez Duran |
| author_facet | Juan Montejo-Hernández Jorge Rico-Fontalvo Jose Cabrales Shuchi Anand María Cristina Martínez-Ávila Claudia Duran-Merino Luis Arias-Restrepo Camilo Andrés Gómez Duran |
| author_sort | Juan Montejo-Hernández |
| collection | DOAJ |
| description | Background. The syndrome of tubulointerstitial nephritis and uveitis (TINU) is a rare oculorenal condition, mainly seen in children and women. The underlying cause of this disease is unknown. Case Presentation. We report a 24-year-old male without any past medical history, diagnosed with bilateral uveitis and azotemia. Biopsy revealed tubulointerstitial nephritis, consistent with TINU syndrome. Fluorescein angiogram revealed peripheral retinal vasculitis. Discussion. TINU is a rare disorder that needs to be distinguished from sarcoidosis, Sjogren’s disease, and tuberculosis. Treatment is indicated in patients with progressive renal insufficiency, consisting of steroid therapy. Most patients recover kidney function. Its early recognition is important to offer the best chance of organ preservation. |
| format | Article |
| id | doaj-art-f2176e493a89456ca98901f347f40566 |
| institution | Kabale University |
| issn | 2090-665X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-f2176e493a89456ca98901f347f405662025-02-03T06:14:53ZengWileyCase Reports in Nephrology2090-665X2024-01-01202410.1155/2024/3909755TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature ReviewJuan Montejo-Hernández0Jorge Rico-Fontalvo1Jose Cabrales2Shuchi Anand3María Cristina Martínez-Ávila4Claudia Duran-Merino5Luis Arias-Restrepo6Camilo Andrés Gómez Duran7Colombian Association of Nephrology and HypertensionColombian Association of Nephrology and HypertensionDivision of NephrologyDivision of NephrologyEpidemiology and Public HealthSan Diego Ophthalmology ClinicDepartment of PathologyCES UniversityBackground. The syndrome of tubulointerstitial nephritis and uveitis (TINU) is a rare oculorenal condition, mainly seen in children and women. The underlying cause of this disease is unknown. Case Presentation. We report a 24-year-old male without any past medical history, diagnosed with bilateral uveitis and azotemia. Biopsy revealed tubulointerstitial nephritis, consistent with TINU syndrome. Fluorescein angiogram revealed peripheral retinal vasculitis. Discussion. TINU is a rare disorder that needs to be distinguished from sarcoidosis, Sjogren’s disease, and tuberculosis. Treatment is indicated in patients with progressive renal insufficiency, consisting of steroid therapy. Most patients recover kidney function. Its early recognition is important to offer the best chance of organ preservation.http://dx.doi.org/10.1155/2024/3909755 |
| spellingShingle | Juan Montejo-Hernández Jorge Rico-Fontalvo Jose Cabrales Shuchi Anand María Cristina Martínez-Ávila Claudia Duran-Merino Luis Arias-Restrepo Camilo Andrés Gómez Duran TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature Review Case Reports in Nephrology |
| title | TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature Review |
| title_full | TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature Review |
| title_fullStr | TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature Review |
| title_full_unstemmed | TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature Review |
| title_short | TINU: A Multisystemic Inflammatory Disorder—Case Report and Literature Review |
| title_sort | tinu a multisystemic inflammatory disorder case report and literature review |
| url | http://dx.doi.org/10.1155/2024/3909755 |
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