Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation
Abstract The World Health Organization (WHO) reports that by 2050, nearly 2.5 billion people are expected to have some degree of hearing loss (HL) and at least 700 million will need hearing rehabilitation. Therefore, there is an urgent need to develop treatment strategies for HL. At present, the mai...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202410919 |
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| author | Zhe Li Yijia Gao Xingyu Chen Lei Xu Zhou Li Renjie Chai |
| author_facet | Zhe Li Yijia Gao Xingyu Chen Lei Xu Zhou Li Renjie Chai |
| author_sort | Zhe Li |
| collection | DOAJ |
| description | Abstract The World Health Organization (WHO) reports that by 2050, nearly 2.5 billion people are expected to have some degree of hearing loss (HL) and at least 700 million will need hearing rehabilitation. Therefore, there is an urgent need to develop treatment strategies for HL. At present, the main treatment strategies for HL are hearing aids and cochlear implants (CIs), which cannot achieve a radical cure for HL. Relevant studies have shown that the most fundamental treatment strategy for sensorineural hearing loss (SNHL) is to regenerate hair cells and spiral ganglion neurons (SGNs) through stem cells to repair the structure and function of cochlea. In addition, physical stimulation strategies, such as electricity, light, and magnetism have also been used to promote SGN regeneration. This review systematically introduces the classification, principle and latest progress of the existing hearing treatment strategies and summarizes the advantages and disadvantages of each strategy. The research progress of physical regulation mechanism is discussed in detail. Finally, the problems in HL repair strategies are summarized and the future development direction is prospected, which could provide new ideas and technologies for the optimization of hearing treatment strategies and the research of SGN repair and regeneration through physical regulation. |
| format | Article |
| id | doaj-art-f20001f0a9284bde93e81668809edce7 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-f20001f0a9284bde93e81668809edce72025-02-04T13:14:54ZengWileyAdvanced Science2198-38442025-02-01125n/an/a10.1002/advs.202410919Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical RegulationZhe Li0Yijia Gao1Xingyu Chen2Lei Xu3Zhou Li4Renjie Chai5Department of Neurology Aerospace Center Hospital School of Life Beijing Institute of Technology Beijing 100081 ChinaDepartment of Neurology Aerospace Center Hospital School of Life Beijing Institute of Technology Beijing 100081 ChinaDepartment of Neurology Aerospace Center Hospital School of Life Beijing Institute of Technology Beijing 100081 ChinaDepartment of Otolaryngology‐Head and Neck Surgery Shandong Provincial ENT Hospital Shandong University Jinan 250022 ChinaBeijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 ChinaDepartment of Neurology Aerospace Center Hospital School of Life Beijing Institute of Technology Beijing 100081 ChinaAbstract The World Health Organization (WHO) reports that by 2050, nearly 2.5 billion people are expected to have some degree of hearing loss (HL) and at least 700 million will need hearing rehabilitation. Therefore, there is an urgent need to develop treatment strategies for HL. At present, the main treatment strategies for HL are hearing aids and cochlear implants (CIs), which cannot achieve a radical cure for HL. Relevant studies have shown that the most fundamental treatment strategy for sensorineural hearing loss (SNHL) is to regenerate hair cells and spiral ganglion neurons (SGNs) through stem cells to repair the structure and function of cochlea. In addition, physical stimulation strategies, such as electricity, light, and magnetism have also been used to promote SGN regeneration. This review systematically introduces the classification, principle and latest progress of the existing hearing treatment strategies and summarizes the advantages and disadvantages of each strategy. The research progress of physical regulation mechanism is discussed in detail. Finally, the problems in HL repair strategies are summarized and the future development direction is prospected, which could provide new ideas and technologies for the optimization of hearing treatment strategies and the research of SGN repair and regeneration through physical regulation.https://doi.org/10.1002/advs.202410919regenerationshearing lossesspiral ganglion neuronsphysical regulations |
| spellingShingle | Zhe Li Yijia Gao Xingyu Chen Lei Xu Zhou Li Renjie Chai Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation Advanced Science regenerations hearing losses spiral ganglion neurons physical regulations |
| title | Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation |
| title_full | Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation |
| title_fullStr | Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation |
| title_full_unstemmed | Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation |
| title_short | Study on Recovery Strategy of Hearing Loss & SGN Regeneration Under Physical Regulation |
| title_sort | study on recovery strategy of hearing loss sgn regeneration under physical regulation |
| topic | regenerations hearing losses spiral ganglion neurons physical regulations |
| url | https://doi.org/10.1002/advs.202410919 |
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