The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis.

The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis.

<h4>Background</h4>Prior research suggested a differential association of 25-hydroxyvitamin D (25(OH)D) metabolites with type 2 diabetes (T2D), with total 25(OH)D and 25(OH)D3 inversely associated with T2D, but the epimeric form (C3-epi-25(OH)D3) positively associated with T2D. Whether o...

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Main Authors: Ju-Sheng Zheng, Jian'an Luan, Eleni Sofianopoulou, Stephen J Sharp, Felix R Day, Fumiaki Imamura, Thomas E Gundersen, Luca A Lotta, Ivonne Sluijs, Isobel D Stewart, Rupal L Shah, Yvonne T van der Schouw, Eleanor Wheeler, Eva Ardanaz, Heiner Boeing, Miren Dorronsoro, Christina C Dahm, Niki Dimou, Douae El-Fatouhi, Paul W Franks, Guy Fagherazzi, Sara Grioni, José María Huerta, Alicia K Heath, Louise Hansen, Mazda Jenab, Paula Jakszyn, Rudolf Kaaks, Tilman Kühn, Kay-Tee Khaw, Nasser Laouali, Giovanna Masala, Peter M Nilsson, Kim Overvad, Anja Olsen, Salvatore Panico, J Ramón Quirós, Olov Rolandsson, Miguel Rodríguez-Barranco, Carlotta Sacerdote, Annemieke M W Spijkerman, Tammy Y N Tong, Rosario Tumino, Konstantinos K Tsilidis, John Danesh, Elio Riboli, Adam S Butterworth, Claudia Langenberg, Nita G Forouhi, Nicholas J Wareham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-10-01
Series:PLoS Medicine
Online Access:https://doi.org/10.1371/journal.pmed.1003394
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