Volumetric Absorptive Microsampling in Toxicology
Volumetric absorptive microsampling (VAMS) is an emerging technique in clinical and forensic toxicology. It is recognized as a promising alternative to traditional sampling methods, offering an accurate and minimally invasive means of collecting small volumes of biological samples, such as blood, ur...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/13/1/25 |
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| author | Bruno Pires Gonçalo Catarro Sofia Soares Joana Gonçalves Tiago Rosado Mário Barroso André R. T. S. Araujo Eugenia Gallardo |
| author_facet | Bruno Pires Gonçalo Catarro Sofia Soares Joana Gonçalves Tiago Rosado Mário Barroso André R. T. S. Araujo Eugenia Gallardo |
| author_sort | Bruno Pires |
| collection | DOAJ |
| description | Volumetric absorptive microsampling (VAMS) is an emerging technique in clinical and forensic toxicology. It is recognized as a promising alternative to traditional sampling methods, offering an accurate and minimally invasive means of collecting small volumes of biological samples, such as blood, urine, and saliva. Unlike conventional methods, VAMS provides advantages in terms of sample stability, storage, and transportation, as it enables samples to be collected outside laboratory environments without requiring refrigeration. This review explores several VAMS methodologies, with a particular focus on its application for the quantification of drugs and other substances in clinical and forensic toxicology. It compares VAMS to other microsampling techniques, such as dried blood spots (DBSs), highlighting VAMS’s superiority in addressing issues related to sample volume consistency and environmental impact. Despite its advantages, VAMS also presents certain limitations, including higher costs and difficulties in detecting underfilled samples. Overall, VAMS stands out as a microsampling technique with the potential to enhance patient compliance and operational efficiency, positioning itself as a viable tool for toxicological analysis in both clinical and forensic contexts. |
| format | Article |
| id | doaj-art-f1ebb012082b4bc697259faa5ef70441 |
| institution | Kabale University |
| issn | 2305-6304 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj-art-f1ebb012082b4bc697259faa5ef704412025-01-24T13:50:58ZengMDPI AGToxics2305-63042024-12-011312510.3390/toxics13010025Volumetric Absorptive Microsampling in ToxicologyBruno Pires0Gonçalo Catarro1Sofia Soares2Joana Gonçalves3Tiago Rosado4Mário Barroso5André R. T. S. Araujo6Eugenia Gallardo7Centro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalCentro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalCentro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalCentro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalCentro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalAlphaBiolabs, 14 Webster Court, Carina Park, Warrington WA5 8WD, UKGrupo de Investigação Sobre Problemas Relacionados Com Toxicofilias, Centro Académico Clínico das Beiras (CACB), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalCentro de Investigação em Ciências da Saúde (CICS-UBI), Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, PortugalVolumetric absorptive microsampling (VAMS) is an emerging technique in clinical and forensic toxicology. It is recognized as a promising alternative to traditional sampling methods, offering an accurate and minimally invasive means of collecting small volumes of biological samples, such as blood, urine, and saliva. Unlike conventional methods, VAMS provides advantages in terms of sample stability, storage, and transportation, as it enables samples to be collected outside laboratory environments without requiring refrigeration. This review explores several VAMS methodologies, with a particular focus on its application for the quantification of drugs and other substances in clinical and forensic toxicology. It compares VAMS to other microsampling techniques, such as dried blood spots (DBSs), highlighting VAMS’s superiority in addressing issues related to sample volume consistency and environmental impact. Despite its advantages, VAMS also presents certain limitations, including higher costs and difficulties in detecting underfilled samples. Overall, VAMS stands out as a microsampling technique with the potential to enhance patient compliance and operational efficiency, positioning itself as a viable tool for toxicological analysis in both clinical and forensic contexts.https://www.mdpi.com/2305-6304/13/1/25volumetric absorptive microsamplingclinical toxicologyforensic toxicology |
| spellingShingle | Bruno Pires Gonçalo Catarro Sofia Soares Joana Gonçalves Tiago Rosado Mário Barroso André R. T. S. Araujo Eugenia Gallardo Volumetric Absorptive Microsampling in Toxicology Toxics volumetric absorptive microsampling clinical toxicology forensic toxicology |
| title | Volumetric Absorptive Microsampling in Toxicology |
| title_full | Volumetric Absorptive Microsampling in Toxicology |
| title_fullStr | Volumetric Absorptive Microsampling in Toxicology |
| title_full_unstemmed | Volumetric Absorptive Microsampling in Toxicology |
| title_short | Volumetric Absorptive Microsampling in Toxicology |
| title_sort | volumetric absorptive microsampling in toxicology |
| topic | volumetric absorptive microsampling clinical toxicology forensic toxicology |
| url | https://www.mdpi.com/2305-6304/13/1/25 |
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