Tear film lipid layer thickness and blink dynamics in patients with blepharospasm
Abstract Background This study investigates the effect of botulinum toxin A on lipid layer thickness (LLT) and blink dynamics in patients with benign essential blepharospasm (BEB) compared to dry eye disease (DED) patients. Methods We reviewed the medical records of patients with dry eye disease (DE...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-025-03852-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594944585367552 |
|---|---|
| author | Ji-Sun Paik Min Jeong Kwon Ga Hee Nam Kyungdo Han Woong-Joo Whang Ho Sik Hwang Suk-Woo Yang Hyun-Seung Kim Kyung Sun Na Won-Kyung Cho |
| author_facet | Ji-Sun Paik Min Jeong Kwon Ga Hee Nam Kyungdo Han Woong-Joo Whang Ho Sik Hwang Suk-Woo Yang Hyun-Seung Kim Kyung Sun Na Won-Kyung Cho |
| author_sort | Ji-Sun Paik |
| collection | DOAJ |
| description | Abstract Background This study investigates the effect of botulinum toxin A on lipid layer thickness (LLT) and blink dynamics in patients with benign essential blepharospasm (BEB) compared to dry eye disease (DED) patients. Methods We reviewed the medical records of patients with dry eye disease (DED) and BEB treated with botulinum toxin A (BoT A) injections. Data on demographics, lipid layer thickness (LLT), meiboscore, and blink dynamics measured using a LipiView II interferometer before and 2 months after BoT A were collected. Results Each 28 eyes from 28 patients with BEB and age- and sex-matched patients with DED were included. When comparing blink dynamics, complete blink rate was significantly higher in the pre-injection BEB group compared to the DED group (5.25 ± 4.32 times/20 s vs. 2.43 ± 2.82 times/20 s, p = 0.0055). In tear film lipid profiles analyzed in BEB patients at pre-injection and 2-month follow-up after injection, average LLT significantly increased after injection (72.4 ± 22.7 nm to 83.0 ± 22.2 nm, p = 0.0215). Diabetes and young age were associated factors influencing the LLT increase. Significant increase in LLT was observed post-injection, with specific demographic factors, including diabetes and age, associated with this improvement. Additionally, blink dynamics showed a decrease in complete blink rate post-injection. Conclusions These findings suggest that BoT-A may alleviate BEB symptoms, but ophthalmologists should carefully interpret LLT and blink patterns in BEB patients due to potential overestimations of blink efficacy by the interferometer. |
| format | Article |
| id | doaj-art-f1eb93ce9aa3475d8b03b2a3aed93c92 |
| institution | Kabale University |
| issn | 1471-2415 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj-art-f1eb93ce9aa3475d8b03b2a3aed93c922025-01-19T12:14:29ZengBMCBMC Ophthalmology1471-24152025-01-012511610.1186/s12886-025-03852-zTear film lipid layer thickness and blink dynamics in patients with blepharospasmJi-Sun Paik0Min Jeong Kwon1Ga Hee Nam2Kyungdo Han3Woong-Joo Whang4Ho Sik Hwang5Suk-Woo Yang6Hyun-Seung Kim7Kyung Sun Na8Won-Kyung Cho9Department of Ophthalmology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Statistics and Actuarial Science, Soongsil UniversityDepartment of Ophthalmology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Ophthalmology, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaAbstract Background This study investigates the effect of botulinum toxin A on lipid layer thickness (LLT) and blink dynamics in patients with benign essential blepharospasm (BEB) compared to dry eye disease (DED) patients. Methods We reviewed the medical records of patients with dry eye disease (DED) and BEB treated with botulinum toxin A (BoT A) injections. Data on demographics, lipid layer thickness (LLT), meiboscore, and blink dynamics measured using a LipiView II interferometer before and 2 months after BoT A were collected. Results Each 28 eyes from 28 patients with BEB and age- and sex-matched patients with DED were included. When comparing blink dynamics, complete blink rate was significantly higher in the pre-injection BEB group compared to the DED group (5.25 ± 4.32 times/20 s vs. 2.43 ± 2.82 times/20 s, p = 0.0055). In tear film lipid profiles analyzed in BEB patients at pre-injection and 2-month follow-up after injection, average LLT significantly increased after injection (72.4 ± 22.7 nm to 83.0 ± 22.2 nm, p = 0.0215). Diabetes and young age were associated factors influencing the LLT increase. Significant increase in LLT was observed post-injection, with specific demographic factors, including diabetes and age, associated with this improvement. Additionally, blink dynamics showed a decrease in complete blink rate post-injection. Conclusions These findings suggest that BoT-A may alleviate BEB symptoms, but ophthalmologists should carefully interpret LLT and blink patterns in BEB patients due to potential overestimations of blink efficacy by the interferometer.https://doi.org/10.1186/s12886-025-03852-zBlepharospasmBlink dynamicsBotulinum toxin ALipiViewLipid layer thickness |
| spellingShingle | Ji-Sun Paik Min Jeong Kwon Ga Hee Nam Kyungdo Han Woong-Joo Whang Ho Sik Hwang Suk-Woo Yang Hyun-Seung Kim Kyung Sun Na Won-Kyung Cho Tear film lipid layer thickness and blink dynamics in patients with blepharospasm BMC Ophthalmology Blepharospasm Blink dynamics Botulinum toxin A LipiView Lipid layer thickness |
| title | Tear film lipid layer thickness and blink dynamics in patients with blepharospasm |
| title_full | Tear film lipid layer thickness and blink dynamics in patients with blepharospasm |
| title_fullStr | Tear film lipid layer thickness and blink dynamics in patients with blepharospasm |
| title_full_unstemmed | Tear film lipid layer thickness and blink dynamics in patients with blepharospasm |
| title_short | Tear film lipid layer thickness and blink dynamics in patients with blepharospasm |
| title_sort | tear film lipid layer thickness and blink dynamics in patients with blepharospasm |
| topic | Blepharospasm Blink dynamics Botulinum toxin A LipiView Lipid layer thickness |
| url | https://doi.org/10.1186/s12886-025-03852-z |
| work_keys_str_mv | AT jisunpaik tearfilmlipidlayerthicknessandblinkdynamicsinpatientswithblepharospasm AT minjeongkwon tearfilmlipidlayerthicknessandblinkdynamicsinpatientswithblepharospasm AT gaheenam tearfilmlipidlayerthicknessandblinkdynamicsinpatientswithblepharospasm AT kyungdohan tearfilmlipidlayerthicknessandblinkdynamicsinpatientswithblepharospasm AT woongjoowhang tearfilmlipidlayerthicknessandblinkdynamicsinpatientswithblepharospasm AT hosikhwang tearfilmlipidlayerthicknessandblinkdynamicsinpatientswithblepharospasm AT sukwooyang tearfilmlipidlayerthicknessandblinkdynamicsinpatientswithblepharospasm AT hyunseungkim tearfilmlipidlayerthicknessandblinkdynamicsinpatientswithblepharospasm AT kyungsunna tearfilmlipidlayerthicknessandblinkdynamicsinpatientswithblepharospasm AT wonkyungcho tearfilmlipidlayerthicknessandblinkdynamicsinpatientswithblepharospasm |