Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

Alectinib-Loaded Chitosan–Alginate Nanoparticles: A Novel Synthesis Method with In Vitro and In Vivo Evaluations

<b>Background/Objectives</b>: Non-small cell lung cancer (NSCLC) constitutes over 84% of all lung cancer cases and is a leading cause of cancer-related mortality globally. Alectinib, a second-generation anaplastic lymphoma kinase (ALK) inhibitor, is effective in ALK-positive NSCLC; howev...

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Bibliographic Details
Main Authors: Tha’er Ata, Israa Al-Ani, Nida Karameh, Mahmood R. Atta, Wael Abu Dayyih
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceutics
Subjects:
Alectinib
chitosan
alginate
nanoparticles
ion gelation
bioavailability
Online Access:https://www.mdpi.com/1999-4923/17/4/492
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