Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A Comparative Study

Objective. This study compared acute and late effect of single-bout endurance training (ET) and high-intensity interval training (HIIT) on the plasma levels of four inflammatory cytokines and C-reactive protein and insulin-like growth factor 1. Design. Cohort study with repeated-measures design. Met...

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Main Authors: Felix Kaspar, Herbert F. Jelinek, Steven Perkins, Hayder A. Al-Aubaidy, Bev deJong, Eugene Butkowski
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2016/5474837
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author Felix Kaspar
Herbert F. Jelinek
Steven Perkins
Hayder A. Al-Aubaidy
Bev deJong
Eugene Butkowski
author_facet Felix Kaspar
Herbert F. Jelinek
Steven Perkins
Hayder A. Al-Aubaidy
Bev deJong
Eugene Butkowski
author_sort Felix Kaspar
collection DOAJ
description Objective. This study compared acute and late effect of single-bout endurance training (ET) and high-intensity interval training (HIIT) on the plasma levels of four inflammatory cytokines and C-reactive protein and insulin-like growth factor 1. Design. Cohort study with repeated-measures design. Methods. Seven healthy untrained volunteers completed a single bout of ET and HIIT on a cycle ergometer. ET and HIIT sessions were held in random order and at least 7 days apart. Blood was drawn before the interventions and 30 min and 2 days after the training sessions. Plasma samples were analyzed with ELISA for the interleukins (IL), IL-1β, IL-6, and IL-10, monocyte chemoattractant protein-1 (MCP-1), insulin growth factor 1 (IGF-1), and C-reactive protein (CRP). Statistical analysis was with Wilcoxon signed-rank tests. Results. ET led to both a significant acute and long-term inflammatory response with a significant decrease at 30 minutes after exercise in the IL-6/IL-10 ratio (−20%; p=0.047) and a decrease of MCP-1 (−17.9%; p=0.03). Conclusion. This study demonstrates that ET affects the inflammatory response more adversely at 30 minutes after exercise compared to HIIT. However, this is compensated by a significant decrease in MCP-1 at two days associated with a reduced risk of atherosclerosis.
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spelling doaj-art-f1b8e2ead6084a37b7029fa58d1c358f2025-08-20T03:20:44ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/54748375474837Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A Comparative StudyFelix Kaspar0Herbert F. Jelinek1Steven Perkins2Hayder A. Al-Aubaidy3Bev deJong4Eugene Butkowski5Department of Biotechnology, Institute for Biochemistry and Biotechnology, Technical University Braunschweig, 38126 Braunschweig, GermanySchool of Community Health, Charles Sturt University, Albury, NSW 2640, AustraliaSchool of Community Health, Charles Sturt University, Albury, NSW 2640, AustraliaSchool of Medicine, University of Tasmania, Hobart, TAS 7001, AustraliaSchool of Community Health, Charles Sturt University, Albury, NSW 2640, AustraliaSchool of Community Health, Charles Sturt University, Albury, NSW 2640, AustraliaObjective. This study compared acute and late effect of single-bout endurance training (ET) and high-intensity interval training (HIIT) on the plasma levels of four inflammatory cytokines and C-reactive protein and insulin-like growth factor 1. Design. Cohort study with repeated-measures design. Methods. Seven healthy untrained volunteers completed a single bout of ET and HIIT on a cycle ergometer. ET and HIIT sessions were held in random order and at least 7 days apart. Blood was drawn before the interventions and 30 min and 2 days after the training sessions. Plasma samples were analyzed with ELISA for the interleukins (IL), IL-1β, IL-6, and IL-10, monocyte chemoattractant protein-1 (MCP-1), insulin growth factor 1 (IGF-1), and C-reactive protein (CRP). Statistical analysis was with Wilcoxon signed-rank tests. Results. ET led to both a significant acute and long-term inflammatory response with a significant decrease at 30 minutes after exercise in the IL-6/IL-10 ratio (−20%; p=0.047) and a decrease of MCP-1 (−17.9%; p=0.03). Conclusion. This study demonstrates that ET affects the inflammatory response more adversely at 30 minutes after exercise compared to HIIT. However, this is compensated by a significant decrease in MCP-1 at two days associated with a reduced risk of atherosclerosis.http://dx.doi.org/10.1155/2016/5474837
spellingShingle Felix Kaspar
Herbert F. Jelinek
Steven Perkins
Hayder A. Al-Aubaidy
Bev deJong
Eugene Butkowski
Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A Comparative Study
Mediators of Inflammation
title Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A Comparative Study
title_full Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A Comparative Study
title_fullStr Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A Comparative Study
title_full_unstemmed Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A Comparative Study
title_short Acute-Phase Inflammatory Response to Single-Bout HIIT and Endurance Training: A Comparative Study
title_sort acute phase inflammatory response to single bout hiit and endurance training a comparative study
url http://dx.doi.org/10.1155/2016/5474837
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