The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi)
Haemophilus influenzae is divided into typeable or nontypeable strains based on the presence or absence of a polysaccharide capsule. The typeable strains (such as type b) are an important cause of systemic infection, whilst the nontypeable strains (designated as NTHi) are predominantly respiratory m...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/706376 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566932260257792 |
|---|---|
| author | Paul T. King Roleen Sharma |
| author_facet | Paul T. King Roleen Sharma |
| author_sort | Paul T. King |
| collection | DOAJ |
| description | Haemophilus influenzae is divided into typeable or nontypeable strains based on the presence or absence of a polysaccharide capsule. The typeable strains (such as type b) are an important cause of systemic infection, whilst the nontypeable strains (designated as NTHi) are predominantly respiratory mucosal pathogens. NTHi is present as part of the normal microbiome in the nasopharynx, from where it may spread down to the lower respiratory tract. In this context it is no longer a commensal and becomes an important respiratory pathogen associated with a range of common conditions including bronchitis, bronchiectasis, pneumonia, and particularly chronic obstructive pulmonary disease. NTHi induces a strong inflammatory response in the respiratory tract with activation of immune responses, which often fail to clear the bacteria from the lung. This results in recurrent/persistent infection and chronic inflammation with consequent lung pathology. This review will summarise the current literature about the lung immune response to nontypeable Haemophilus influenzae, a topic that has important implications for patient management. |
| format | Article |
| id | doaj-art-f1b3271e0a0a48a1a163ac792a357521 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f1b3271e0a0a48a1a163ac792a3575212025-02-03T01:02:49ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/706376706376The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi)Paul T. King0Roleen Sharma1Monash Lung and Sleep, Monash Medical Centre, Melbourne, VIC 3168, AustraliaMonash Lung and Sleep, Monash Medical Centre, Melbourne, VIC 3168, AustraliaHaemophilus influenzae is divided into typeable or nontypeable strains based on the presence or absence of a polysaccharide capsule. The typeable strains (such as type b) are an important cause of systemic infection, whilst the nontypeable strains (designated as NTHi) are predominantly respiratory mucosal pathogens. NTHi is present as part of the normal microbiome in the nasopharynx, from where it may spread down to the lower respiratory tract. In this context it is no longer a commensal and becomes an important respiratory pathogen associated with a range of common conditions including bronchitis, bronchiectasis, pneumonia, and particularly chronic obstructive pulmonary disease. NTHi induces a strong inflammatory response in the respiratory tract with activation of immune responses, which often fail to clear the bacteria from the lung. This results in recurrent/persistent infection and chronic inflammation with consequent lung pathology. This review will summarise the current literature about the lung immune response to nontypeable Haemophilus influenzae, a topic that has important implications for patient management.http://dx.doi.org/10.1155/2015/706376 |
| spellingShingle | Paul T. King Roleen Sharma The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi) Journal of Immunology Research |
| title | The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi) |
| title_full | The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi) |
| title_fullStr | The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi) |
| title_full_unstemmed | The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi) |
| title_short | The Lung Immune Response to Nontypeable Haemophilus influenzae (Lung Immunity to NTHi) |
| title_sort | lung immune response to nontypeable haemophilus influenzae lung immunity to nthi |
| url | http://dx.doi.org/10.1155/2015/706376 |
| work_keys_str_mv | AT paultking thelungimmuneresponsetonontypeablehaemophilusinfluenzaelungimmunitytonthi AT roleensharma thelungimmuneresponsetonontypeablehaemophilusinfluenzaelungimmunitytonthi AT paultking lungimmuneresponsetonontypeablehaemophilusinfluenzaelungimmunitytonthi AT roleensharma lungimmuneresponsetonontypeablehaemophilusinfluenzaelungimmunitytonthi |