Crosstalk between Macrophages and Mesenchymal Stem Cells Regulated by Biomaterials and Its Role in Bone Regeneration
Impaired bone healing caused by severe trauma, infection, and tumor resection is an extremely common phenomenon. Therefore, the treatment of bone defects represents a major clinical challenge worldwide. In such situations, the application of biomaterials is necessary for filling defects and promotin...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2021/9954205 |
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| author | Fan Gong Thomas Groth Chenlin Tu Mingyan Zhao Xinqia Huang Jiaqi Chu |
| author_facet | Fan Gong Thomas Groth Chenlin Tu Mingyan Zhao Xinqia Huang Jiaqi Chu |
| author_sort | Fan Gong |
| collection | DOAJ |
| description | Impaired bone healing caused by severe trauma, infection, and tumor resection is an extremely common phenomenon. Therefore, the treatment of bone defects represents a major clinical challenge worldwide. In such situations, the application of biomaterials is necessary for filling defects and promoting bone regeneration. Bone repair biomaterials having osteoconductive and osteoinductive properties can act as an appropriate template for the formation of new bone and induce the osteogenic differentiation of preosteocytes and stem cells. Thus, the influence of biomaterials on the regulation of osteogenesis of mesenchymal stem cells (MSCs) has been widely studied. However, immune response is also critical in bone healing; macrophages play pivotal and dynamic roles in bone regeneration. The interfacial properties of biomaterials that affect the adsorption of proteins and the adhesion function of cells require great attention in the field of bone tissue engineering because they are related to the crosstalk with the immune and bone or stem cells. Thus, selection of biomaterials or specific surface coatings may reduce local undesirable inflammatory responses and promote bone regeneration. This review provides a detailed overview of bone regeneration mechanisms and the interaction between immune cells and MSCs. Moreover, the influence of biomaterials on the regulation of functions of MSCs and macrophages and the macrophage-related inflammatory response triggered by biomaterials and its specific role in osteogenesis are discussed. |
| format | Article |
| id | doaj-art-f1a88ca78cc24542b6372ad45b019da5 |
| institution | Kabale University |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-f1a88ca78cc24542b6372ad45b019da52025-02-03T07:23:57ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422021-01-01202110.1155/2021/99542059954205Crosstalk between Macrophages and Mesenchymal Stem Cells Regulated by Biomaterials and Its Role in Bone RegenerationFan Gong0Thomas Groth1Chenlin Tu2Mingyan Zhao3Xinqia Huang4Jiaqi Chu5Stem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Renmin Dadao Road 57, Xiashan District, Zhanjiang 524001, ChinaDepartment Biomedical Materials, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Heinrich-Damerow-Strasse 4, 06120 Halle (Saale), GermanyStem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Renmin Dadao Road 57, Xiashan District, Zhanjiang 524001, ChinaStem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Renmin Dadao Road 57, Xiashan District, Zhanjiang 524001, ChinaStem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Renmin Dadao Road 57, Xiashan District, Zhanjiang 524001, ChinaStem Cell Research and Cellular Therapy Center, Affiliated Hospital of Guangdong Medical University, Renmin Dadao Road 57, Xiashan District, Zhanjiang 524001, ChinaImpaired bone healing caused by severe trauma, infection, and tumor resection is an extremely common phenomenon. Therefore, the treatment of bone defects represents a major clinical challenge worldwide. In such situations, the application of biomaterials is necessary for filling defects and promoting bone regeneration. Bone repair biomaterials having osteoconductive and osteoinductive properties can act as an appropriate template for the formation of new bone and induce the osteogenic differentiation of preosteocytes and stem cells. Thus, the influence of biomaterials on the regulation of osteogenesis of mesenchymal stem cells (MSCs) has been widely studied. However, immune response is also critical in bone healing; macrophages play pivotal and dynamic roles in bone regeneration. The interfacial properties of biomaterials that affect the adsorption of proteins and the adhesion function of cells require great attention in the field of bone tissue engineering because they are related to the crosstalk with the immune and bone or stem cells. Thus, selection of biomaterials or specific surface coatings may reduce local undesirable inflammatory responses and promote bone regeneration. This review provides a detailed overview of bone regeneration mechanisms and the interaction between immune cells and MSCs. Moreover, the influence of biomaterials on the regulation of functions of MSCs and macrophages and the macrophage-related inflammatory response triggered by biomaterials and its specific role in osteogenesis are discussed.http://dx.doi.org/10.1155/2021/9954205 |
| spellingShingle | Fan Gong Thomas Groth Chenlin Tu Mingyan Zhao Xinqia Huang Jiaqi Chu Crosstalk between Macrophages and Mesenchymal Stem Cells Regulated by Biomaterials and Its Role in Bone Regeneration Advances in Materials Science and Engineering |
| title | Crosstalk between Macrophages and Mesenchymal Stem Cells Regulated by Biomaterials and Its Role in Bone Regeneration |
| title_full | Crosstalk between Macrophages and Mesenchymal Stem Cells Regulated by Biomaterials and Its Role in Bone Regeneration |
| title_fullStr | Crosstalk between Macrophages and Mesenchymal Stem Cells Regulated by Biomaterials and Its Role in Bone Regeneration |
| title_full_unstemmed | Crosstalk between Macrophages and Mesenchymal Stem Cells Regulated by Biomaterials and Its Role in Bone Regeneration |
| title_short | Crosstalk between Macrophages and Mesenchymal Stem Cells Regulated by Biomaterials and Its Role in Bone Regeneration |
| title_sort | crosstalk between macrophages and mesenchymal stem cells regulated by biomaterials and its role in bone regeneration |
| url | http://dx.doi.org/10.1155/2021/9954205 |
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