Inhibition of ATM or ATR in combination with hypo-fractionated radiotherapy leads to a different immunophenotype on transcript and protein level in HNSCC

Inhibition of ATM or ATR in combination with hypo-fractionated radiotherapy leads to a different immunophenotype on transcript and protein level in HNSCC

BackgroundThe treatment of head and neck tumors remains a challenge due to their reduced radiosensitivity. Small molecule kinase inhibitors (smKI) that inhibit the DNA damage response, may increase the radiosensitivity of tumor cells. However, little is known about how the immunophenotype of the tum...

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Bibliographic Details
Main Authors: Julia Meidenbauer, Matthias Wachter, Sebastian R. Schulz, Nada Mostafa, Lilli Zülch, Benjamin Frey, Rainer Fietkau, Udo S. Gaipl, Tina Jost
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Oncology
Subjects:
HNSCC
DNA damage repair
kinase inhibitors
immunomodulation
ATM inhibition
ATR inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1460150/full
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