Paradoxical association of C-reactive protein with endothelial function in rheumatoid arthritis.
<h4>Background</h4>Within the general population, levels of C-reactive protein (CRP) are positively associated with atherosclerotic cardiovascular disease (CVD). Whether CRP is causally implicated in atherogenesis or is the results of atherosclerosis is disputed. A role of CRP to protect...
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Public Library of Science (PLoS)
2010-04-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010242&type=printable |
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| author | Michael V Holmes Benyu Jiang Karen McNeill Melinda Wong Stephen P Oakley Bruce Kirkham Phil J Chowienczyk |
| author_facet | Michael V Holmes Benyu Jiang Karen McNeill Melinda Wong Stephen P Oakley Bruce Kirkham Phil J Chowienczyk |
| author_sort | Michael V Holmes |
| collection | DOAJ |
| description | <h4>Background</h4>Within the general population, levels of C-reactive protein (CRP) are positively associated with atherosclerotic cardiovascular disease (CVD). Whether CRP is causally implicated in atherogenesis or is the results of atherosclerosis is disputed. A role of CRP to protect endothelium-derived nitric oxide (EDNO) has been suggested. We examined the association of CRP with EDNO-dependent vasomotor function and subclinical measures of atherosclerosis and arteriosclerosis in patients with raised CRP resulting from rheumatoid arthritis (RA).<h4>Methodology/principal findings</h4>Patients with RA (n = 59) and healthy control subjects (n = 123), underwent measures of high sensitivity CRP, flow-mediated dilation (FMD, dependent on EDNO), intima-media thickness (IMT, a measure of subclinical atherosclerosis) and aortic pulse wave velocity (PWV, a measure of arteriosclerosis). IMT and PWV were elevated in patients with RA compared to controls but FMD was similar in the two groups. In patients with RA, IMT and PWV were not correlated with CRP but FMD was positively independently correlated with CRP (P<0.01).<h4>Conclusions/significance</h4>These findings argue against a causal role of CRP in atherogenesis and are consistent with a protective effect of CRP on EDNO bioavailability. |
| format | Article |
| id | doaj-art-f18e8a06a48c43f380831dab0a7cf71c |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2010-04-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-f18e8a06a48c43f380831dab0a7cf71c2025-08-20T02:31:52ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-04-0154e1024210.1371/journal.pone.0010242Paradoxical association of C-reactive protein with endothelial function in rheumatoid arthritis.Michael V HolmesBenyu JiangKaren McNeillMelinda WongStephen P OakleyBruce KirkhamPhil J Chowienczyk<h4>Background</h4>Within the general population, levels of C-reactive protein (CRP) are positively associated with atherosclerotic cardiovascular disease (CVD). Whether CRP is causally implicated in atherogenesis or is the results of atherosclerosis is disputed. A role of CRP to protect endothelium-derived nitric oxide (EDNO) has been suggested. We examined the association of CRP with EDNO-dependent vasomotor function and subclinical measures of atherosclerosis and arteriosclerosis in patients with raised CRP resulting from rheumatoid arthritis (RA).<h4>Methodology/principal findings</h4>Patients with RA (n = 59) and healthy control subjects (n = 123), underwent measures of high sensitivity CRP, flow-mediated dilation (FMD, dependent on EDNO), intima-media thickness (IMT, a measure of subclinical atherosclerosis) and aortic pulse wave velocity (PWV, a measure of arteriosclerosis). IMT and PWV were elevated in patients with RA compared to controls but FMD was similar in the two groups. In patients with RA, IMT and PWV were not correlated with CRP but FMD was positively independently correlated with CRP (P<0.01).<h4>Conclusions/significance</h4>These findings argue against a causal role of CRP in atherogenesis and are consistent with a protective effect of CRP on EDNO bioavailability.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010242&type=printable |
| spellingShingle | Michael V Holmes Benyu Jiang Karen McNeill Melinda Wong Stephen P Oakley Bruce Kirkham Phil J Chowienczyk Paradoxical association of C-reactive protein with endothelial function in rheumatoid arthritis. PLoS ONE |
| title | Paradoxical association of C-reactive protein with endothelial function in rheumatoid arthritis. |
| title_full | Paradoxical association of C-reactive protein with endothelial function in rheumatoid arthritis. |
| title_fullStr | Paradoxical association of C-reactive protein with endothelial function in rheumatoid arthritis. |
| title_full_unstemmed | Paradoxical association of C-reactive protein with endothelial function in rheumatoid arthritis. |
| title_short | Paradoxical association of C-reactive protein with endothelial function in rheumatoid arthritis. |
| title_sort | paradoxical association of c reactive protein with endothelial function in rheumatoid arthritis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0010242&type=printable |
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