Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?
We report a case of a female patient with Durie-Salmon stage 3A/ISS stage I IgG kappa multiple myeloma (MM) who developed encephalopathy after high-dose melphalan and hematopoietic stem cell transplant (HSCT). The most common etiologies for encephalopathy such as infection, narcotic medications, met...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2012/942795 |
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| author | Diógenes Alayón-Laguer Melissa Alsina Jose L. Ochoa-Bayona Ernesto Ayala |
| author_facet | Diógenes Alayón-Laguer Melissa Alsina Jose L. Ochoa-Bayona Ernesto Ayala |
| author_sort | Diógenes Alayón-Laguer |
| collection | DOAJ |
| description | We report a case of a female patient with Durie-Salmon stage 3A/ISS stage I IgG kappa multiple myeloma (MM) who developed encephalopathy after high-dose melphalan and hematopoietic stem cell transplant (HSCT). The most common etiologies for encephalopathy such as infection, narcotic medications, metabolic-electrolyte disturbance, stroke, and central nervous system (CNS) hemorrhages were ruled out. The patient recovered from the altered mental status spontaneously. The possibilities of melphalan-induced encephalopathy versus critical-state delirium versus hypercytokinemia induce encephalopathy were contemplated. |
| format | Article |
| id | doaj-art-f189b0626517417f8fbd1c5b4b3a2533 |
| institution | Kabale University |
| issn | 2090-6943 2090-6951 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-f189b0626517417f8fbd1c5b4b3a25332025-02-03T06:13:14ZengWileyCase Reports in Transplantation2090-69432090-69512012-01-01201210.1155/2012/942795942795Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation?Diógenes Alayón-Laguer0Melissa Alsina1Jose L. Ochoa-Bayona2Ernesto Ayala3Hematology-Oncology Program San Juan City Hospital and VA Caribbean Healthcare System, 10 Calle Casia, San Juan, PR 00921, USABlood an Marrow Transplantation Program, Moffitt Cancer Center, Tampa, FL 33612, USABlood an Marrow Transplantation Program, Moffitt Cancer Center, Tampa, FL 33612, USABlood an Marrow Transplantation Program, Moffitt Cancer Center, Tampa, FL 33612, USAWe report a case of a female patient with Durie-Salmon stage 3A/ISS stage I IgG kappa multiple myeloma (MM) who developed encephalopathy after high-dose melphalan and hematopoietic stem cell transplant (HSCT). The most common etiologies for encephalopathy such as infection, narcotic medications, metabolic-electrolyte disturbance, stroke, and central nervous system (CNS) hemorrhages were ruled out. The patient recovered from the altered mental status spontaneously. The possibilities of melphalan-induced encephalopathy versus critical-state delirium versus hypercytokinemia induce encephalopathy were contemplated.http://dx.doi.org/10.1155/2012/942795 |
| spellingShingle | Diógenes Alayón-Laguer Melissa Alsina Jose L. Ochoa-Bayona Ernesto Ayala Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation? Case Reports in Transplantation |
| title | Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation? |
| title_full | Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation? |
| title_fullStr | Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation? |
| title_full_unstemmed | Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation? |
| title_short | Melphalan Culprit or Confounder in Acute Encephalopathy during Autologous Hematopoietic Stem Cell Transplantation? |
| title_sort | melphalan culprit or confounder in acute encephalopathy during autologous hematopoietic stem cell transplantation |
| url | http://dx.doi.org/10.1155/2012/942795 |
| work_keys_str_mv | AT diogenesalayonlaguer melphalanculpritorconfounderinacuteencephalopathyduringautologoushematopoieticstemcelltransplantation AT melissaalsina melphalanculpritorconfounderinacuteencephalopathyduringautologoushematopoieticstemcelltransplantation AT joselochoabayona melphalanculpritorconfounderinacuteencephalopathyduringautologoushematopoieticstemcelltransplantation AT ernestoayala melphalanculpritorconfounderinacuteencephalopathyduringautologoushematopoieticstemcelltransplantation |