Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1

Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1

Abstract Aerobic glycolysis is a hallmark of cancer and is regulated by growth factors, protein kinases and transcription factors. However, it remains poorly understood how these components interact to regulate aerobic glycolysis coordinately. Here, we show that sine oculis homeobox 1 (SIX1) phospho...

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Main Authors: Yanni Lin, Ling Li, Bin Yuan, Fei Luo, Xiujuan Zhang, Yuanjun Yang, Shaliu Luo, Jing Lin, Tianxing Ye, Youzhi Zhang, Shan Gao, Qinong Ye
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-024-02034-5
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