Argonaute 2 targets viral transcripts but not genomes of RNA viruses during antiviral RNA interference in Drosophila.

Argonaute 2 targets viral transcripts but not genomes of RNA viruses during antiviral RNA interference in Drosophila.

RNA interference (RNAi) mediated by the small interfering RNA (siRNA) pathway is a major antiviral mechanism in insects. This pathway is triggered when double-stranded RNA (dsRNA) produced during virus replication is recognized by Dicer-2, leading to the formation of virus-derived siRNA duplexes. Th...

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Main Authors: Emanuele G Silva, Isaque J S de Faria, Álvaro G A Ferreira, Thiago Henrique L Jiran, Carlos F Estevez-Castro, Juliana N Armache, Siad C G Amadou, Yann Verdier, Joëlle Vinh, Karim Majzoub, Carine Meignin, Gabrielle Haas, Franck Martin, Jean-Luc Imler, João T Marques
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-02-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012184
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