Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis
Background Vascular calcification is common and progressive in patients with chronic kidney disease. However, the risk factors associated with the progression of vascular calcification in patients receiving maintenance dialysis have not been fully elucidated. Here, we aimed to evaluate vascular calc...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2456690 |
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| author | Dan-Dan Yao Xiao-Wei Yan Yan Zhou Zuo-Lin Li Fang-Xin Qiu |
| author_facet | Dan-Dan Yao Xiao-Wei Yan Yan Zhou Zuo-Lin Li Fang-Xin Qiu |
| author_sort | Dan-Dan Yao |
| collection | DOAJ |
| description | Background Vascular calcification is common and progressive in patients with chronic kidney disease. However, the risk factors associated with the progression of vascular calcification in patients receiving maintenance dialysis have not been fully elucidated. Here, we aimed to evaluate vascular calcification and identify the factors associated with its progression in patients receiving maintenance hemodialysis.Methods This is a prospective longitudinal study that included 374 patients receiving maintenance hemodialysis. The participants received assessments of coronary artery calcification (CAC) and abdominal aortic calcification (AAC), as measured by computed tomography. After the baseline investigation, a 2 years follow-up was performed. We also detected the markers of endothelial injury [E-selectin and soluble intercellular adhesion molecule-1 (sICAM-1)]. Finally, the risk factors affecting the CAC and AAC progression were examined by multivariate logistic regression analysis.Results Among 374 patients, the median [interquartile range (IQR)] age was 54.0 (40.0–62.0) years; 59.9% of patients were male. The median (IQR) follow-up time was 1.9 (1.8–2.0) years for all patients. By the end of 2-year follow-up, progression of vascular calcification (including CAC and AAC) was observed in 58.0% of patients. Further, compared with the patients without progression of vascular calcification, the endothelial injury (including E-selectin and sICAM-1) of patients with progression of vascular calcification was markedly enhanced. Moreover, after adjustment for the confounders, endothelial injury was a risk factor for the progression of vascular calcification.Conclusion The present study indicated that endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance hemodialysis. |
| format | Article |
| id | doaj-art-f159c05d914f4e70a66cad66279e8457 |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-f159c05d914f4e70a66cad66279e84572025-01-27T05:41:27ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2456690Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysisDan-Dan Yao0Xiao-Wei Yan1Yan Zhou2Zuo-Lin Li3Fang-Xin Qiu4Department of Nephrology, Chengyang District People’s Hospital, Qingdao, ChinaInstitute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, ChinaInstitute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, ChinaInstitute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, ChinaDepartment of Nephrology, Chengyang District People’s Hospital, Qingdao, ChinaBackground Vascular calcification is common and progressive in patients with chronic kidney disease. However, the risk factors associated with the progression of vascular calcification in patients receiving maintenance dialysis have not been fully elucidated. Here, we aimed to evaluate vascular calcification and identify the factors associated with its progression in patients receiving maintenance hemodialysis.Methods This is a prospective longitudinal study that included 374 patients receiving maintenance hemodialysis. The participants received assessments of coronary artery calcification (CAC) and abdominal aortic calcification (AAC), as measured by computed tomography. After the baseline investigation, a 2 years follow-up was performed. We also detected the markers of endothelial injury [E-selectin and soluble intercellular adhesion molecule-1 (sICAM-1)]. Finally, the risk factors affecting the CAC and AAC progression were examined by multivariate logistic regression analysis.Results Among 374 patients, the median [interquartile range (IQR)] age was 54.0 (40.0–62.0) years; 59.9% of patients were male. The median (IQR) follow-up time was 1.9 (1.8–2.0) years for all patients. By the end of 2-year follow-up, progression of vascular calcification (including CAC and AAC) was observed in 58.0% of patients. Further, compared with the patients without progression of vascular calcification, the endothelial injury (including E-selectin and sICAM-1) of patients with progression of vascular calcification was markedly enhanced. Moreover, after adjustment for the confounders, endothelial injury was a risk factor for the progression of vascular calcification.Conclusion The present study indicated that endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance hemodialysis.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2456690Endothelial injuryvascular calcificationmaintenance dialysisrisk factor |
| spellingShingle | Dan-Dan Yao Xiao-Wei Yan Yan Zhou Zuo-Lin Li Fang-Xin Qiu Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis Renal Failure Endothelial injury vascular calcification maintenance dialysis risk factor |
| title | Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis |
| title_full | Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis |
| title_fullStr | Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis |
| title_full_unstemmed | Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis |
| title_short | Endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis |
| title_sort | endothelial injury is one of the risk factors for the progression of vascular calcification in patients receiving maintenance dialysis |
| topic | Endothelial injury vascular calcification maintenance dialysis risk factor |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2456690 |
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