Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology
ABSTRACT Using synthetic biology techniques, bacteria have been engineered to serve as microrobots for diagnosing diseases and delivering treatments. These engineered bacteria can be used individually or in combination as microbial consortia. The components within these consortia complement each oth...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Microbial Biotechnology |
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| Online Access: | https://doi.org/10.1111/1751-7915.70080 |
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| author | Kai Jin Yi Huang Hailong Che Yihan Wu |
| author_facet | Kai Jin Yi Huang Hailong Che Yihan Wu |
| author_sort | Kai Jin |
| collection | DOAJ |
| description | ABSTRACT Using synthetic biology techniques, bacteria have been engineered to serve as microrobots for diagnosing diseases and delivering treatments. These engineered bacteria can be used individually or in combination as microbial consortia. The components within these consortia complement each other, enhancing diagnostic accuracy and providing synergistic effects that improve treatment efficacy. The application of microbial therapies in cancer, intestinal diseases, and metabolic disorders underscores their significant potential. The impact of these therapies on the host's native microbiota is crucial, as engineered microbes can modulate and interact with the host's microbial environment, influencing treatment outcomes and overall health. Despite numerous advancements, challenges remain. These include ensuring the long‐term survival and safety of bacteria, developing new chassis microbes and gene editing techniques for non‐model strains, minimising potential toxicity, and understanding bacterial interactions with the host microbiota. This mini‐review examines the current state of engineered bacteria and microbial consortia in disease diagnosis and treatment, highlighting advancements, challenges, and future directions in this promising field. |
| format | Article |
| id | doaj-art-f1480c50dfeb4779af1fa4b52cca177d |
| institution | Kabale University |
| issn | 1751-7915 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Microbial Biotechnology |
| spelling | doaj-art-f1480c50dfeb4779af1fa4b52cca177d2025-01-31T06:26:35ZengWileyMicrobial Biotechnology1751-79152025-01-01181n/an/a10.1111/1751-7915.70080Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic BiologyKai Jin0Yi Huang1Hailong Che2Yihan Wu3Department of Environmental and Chemical Engineering Shanghai University Shanghai ChinaDepartment of Environmental and Chemical Engineering Shanghai University Shanghai ChinaDepartment of Environmental and Chemical Engineering Shanghai University Shanghai ChinaDepartment of Environmental and Chemical Engineering Shanghai University Shanghai ChinaABSTRACT Using synthetic biology techniques, bacteria have been engineered to serve as microrobots for diagnosing diseases and delivering treatments. These engineered bacteria can be used individually or in combination as microbial consortia. The components within these consortia complement each other, enhancing diagnostic accuracy and providing synergistic effects that improve treatment efficacy. The application of microbial therapies in cancer, intestinal diseases, and metabolic disorders underscores their significant potential. The impact of these therapies on the host's native microbiota is crucial, as engineered microbes can modulate and interact with the host's microbial environment, influencing treatment outcomes and overall health. Despite numerous advancements, challenges remain. These include ensuring the long‐term survival and safety of bacteria, developing new chassis microbes and gene editing techniques for non‐model strains, minimising potential toxicity, and understanding bacterial interactions with the host microbiota. This mini‐review examines the current state of engineered bacteria and microbial consortia in disease diagnosis and treatment, highlighting advancements, challenges, and future directions in this promising field.https://doi.org/10.1111/1751-7915.70080biosensorengineered bacterialive biotherapysynthetic biology |
| spellingShingle | Kai Jin Yi Huang Hailong Che Yihan Wu Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology Microbial Biotechnology biosensor engineered bacteria live biotherapy synthetic biology |
| title | Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology |
| title_full | Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology |
| title_fullStr | Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology |
| title_full_unstemmed | Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology |
| title_short | Engineered Bacteria for Disease Diagnosis and Treatment Using Synthetic Biology |
| title_sort | engineered bacteria for disease diagnosis and treatment using synthetic biology |
| topic | biosensor engineered bacteria live biotherapy synthetic biology |
| url | https://doi.org/10.1111/1751-7915.70080 |
| work_keys_str_mv | AT kaijin engineeredbacteriafordiseasediagnosisandtreatmentusingsyntheticbiology AT yihuang engineeredbacteriafordiseasediagnosisandtreatmentusingsyntheticbiology AT hailongche engineeredbacteriafordiseasediagnosisandtreatmentusingsyntheticbiology AT yihanwu engineeredbacteriafordiseasediagnosisandtreatmentusingsyntheticbiology |