Neuroprotective effect of silymarin-loaded nanoliposomes against monosodium glutamate-induced cerebellar motor deficit and Purkinje cell damage in experimental rats via PI3K/AKT pathway activation

Neuroprotective effect of silymarin-loaded nanoliposomes against monosodium glutamate-induced cerebellar motor deficit and Purkinje cell damage in experimental rats via PI3K/AKT pathway activation

Background and aimThis study investigated the ameliorative effect of Silymarin-nanoliposome (SLNPs) against monosodium glutamate (MSG)-induced cerebellar toxicity, illuminating its impact on motor coordination.MethodsForty male Wistar albino rats were divided into four groups. Group I (control group...

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Bibliographic Details
Main Authors: Medhat Taha, Ahmed Alzahrani, Omer Abdelbagi, Rehab M. Bagadood, Naeem F. Qusty, Rami Obaid, Mohammad El-Nablaway, Tourki A. S. Baokbah
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
cerebellar toxicity
monosodium glutamate
silymarin nanoliposomes
oxidative stress
neuroinflammation
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1621240/full
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