Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis
A literature review showed some discrepancies regarding the association of -592C/A with the risk of cervical cancer. To allow more precise analysis of the data by increasing the number of cases studied and more acceptable generalization by considering results from different sources, the present meta...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Genetics Research |
| Online Access: | http://dx.doi.org/10.1155/2022/2319161 |
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| author | Brehima Diakite Yaya Kassogue Mamoudou Maiga Guimogo Dolo Oumar Kassogue Jonah Musa Imran Morhason-Bello Ban Traore Cheick Bougadari Traore Bakarou Kamate Aissata Coulibaly Sekou Bah Sellama Nadifi Robert Murphy Jane L. Holl Lifang Hou |
| author_facet | Brehima Diakite Yaya Kassogue Mamoudou Maiga Guimogo Dolo Oumar Kassogue Jonah Musa Imran Morhason-Bello Ban Traore Cheick Bougadari Traore Bakarou Kamate Aissata Coulibaly Sekou Bah Sellama Nadifi Robert Murphy Jane L. Holl Lifang Hou |
| author_sort | Brehima Diakite |
| collection | DOAJ |
| description | A literature review showed some discrepancies regarding the association of -592C/A with the risk of cervical cancer. To allow more precise analysis of the data by increasing the number of cases studied and more acceptable generalization by considering results from different sources, the present meta-analysis was performed on available published studies that explored the relationship between SNP-592C/A of the IL-10 gene and the risk of cervical cancer. Eleven available studies, including 4187 cases and 3311 controls, were included in this study investigating the relationship between the -592C/A polymorphism of IL-10 and cervical cancer risk. Fixed-effects or random-effects models were performed with pooled odds ratios (ORs). Heterogeneity and bias tests were performed by the inconsistency test and funnel plot, respectively. The overall analysis showed an increased susceptibility to cervical cancer with the -592C/A polymorphism of the IL-10 gene for the recessive model (OR = 1.30, 95% CI = 1.14–1.49), dominant model (OR = 1.36, 95% CI = 1.09–1.70), and additive model (OR = 1.25, 95% CI = 1.09–1.44). Regarding ethnicity, a significant association of the -592C/A polymorphism of the IL-10 gene was linked to an elevated risk of cervical cancer for all genetic models (recessive, dominant, and additive) in the Asian populations and for the recessive and additive models in Caucasians with P<0.05. The -592C/A polymorphism of the IL-10 gene may be considered a risk factor for cervical cancer. |
| format | Article |
| id | doaj-art-f13b6cb8f0d54523834b95b036ae40fd |
| institution | Kabale University |
| issn | 1469-5073 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Genetics Research |
| spelling | doaj-art-f13b6cb8f0d54523834b95b036ae40fd2025-02-03T01:32:26ZengWileyGenetics Research1469-50732022-01-01202210.1155/2022/2319161Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-AnalysisBrehima Diakite0Yaya Kassogue1Mamoudou Maiga2Guimogo Dolo3Oumar Kassogue4Jonah Musa5Imran Morhason-Bello6Ban Traore7Cheick Bougadari Traore8Bakarou Kamate9Aissata Coulibaly10Sekou Bah11Sellama Nadifi12Robert Murphy13Jane L. Holl14Lifang Hou15Centre de Recherche et de Formation sur les Pathologies Moleculaires (CREFPAM)Centre de Recherche et de Formation sur les Pathologies Moleculaires (CREFPAM)Centre de Recherche et de Formation sur les Pathologies Moleculaires (CREFPAM)Centre de Recherche et de Formation sur les Pathologies Moleculaires (CREFPAM)Centre de Recherche et de Formation sur les Pathologies Moleculaires (CREFPAM)Preventive Medicine DepartmentDepartment of Obstetrics and GynecologyFaculty of Sciences and TechniquesCentre de Recherche et de Formation sur les Pathologies Moleculaires (CREFPAM)Centre de Recherche et de Formation sur les Pathologies Moleculaires (CREFPAM)Centre de Recherche et de Formation sur les Pathologies Moleculaires (CREFPAM)Faculty of PharmacyHassan II University Aïn ChockInstitute for Global HealthDepartment of NeurologyPreventive Medicine DepartmentA literature review showed some discrepancies regarding the association of -592C/A with the risk of cervical cancer. To allow more precise analysis of the data by increasing the number of cases studied and more acceptable generalization by considering results from different sources, the present meta-analysis was performed on available published studies that explored the relationship between SNP-592C/A of the IL-10 gene and the risk of cervical cancer. Eleven available studies, including 4187 cases and 3311 controls, were included in this study investigating the relationship between the -592C/A polymorphism of IL-10 and cervical cancer risk. Fixed-effects or random-effects models were performed with pooled odds ratios (ORs). Heterogeneity and bias tests were performed by the inconsistency test and funnel plot, respectively. The overall analysis showed an increased susceptibility to cervical cancer with the -592C/A polymorphism of the IL-10 gene for the recessive model (OR = 1.30, 95% CI = 1.14–1.49), dominant model (OR = 1.36, 95% CI = 1.09–1.70), and additive model (OR = 1.25, 95% CI = 1.09–1.44). Regarding ethnicity, a significant association of the -592C/A polymorphism of the IL-10 gene was linked to an elevated risk of cervical cancer for all genetic models (recessive, dominant, and additive) in the Asian populations and for the recessive and additive models in Caucasians with P<0.05. The -592C/A polymorphism of the IL-10 gene may be considered a risk factor for cervical cancer.http://dx.doi.org/10.1155/2022/2319161 |
| spellingShingle | Brehima Diakite Yaya Kassogue Mamoudou Maiga Guimogo Dolo Oumar Kassogue Jonah Musa Imran Morhason-Bello Ban Traore Cheick Bougadari Traore Bakarou Kamate Aissata Coulibaly Sekou Bah Sellama Nadifi Robert Murphy Jane L. Holl Lifang Hou Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis Genetics Research |
| title | Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis |
| title_full | Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis |
| title_fullStr | Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis |
| title_full_unstemmed | Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis |
| title_short | Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis |
| title_sort | association of the interleukin 10 592c a polymorphism and cervical cancer risk a meta analysis |
| url | http://dx.doi.org/10.1155/2022/2319161 |
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