Glomus Tumor in the Left Submandibular Region: A Rare Case Report and Literature Review
ABSTRACT Background Glomus tumors are rare, benign mesenchymal neoplasms predominantly located in subungual regions of the extremities. Their occurrence in the mandibular region is exceptionally uncommon, presenting unique diagnostic challenges. Only a limited number of submandibular glomus tumors h...
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Wiley
2025-01-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.70113 |
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| author | Huan Liu Chengyao Zhu |
| author_facet | Huan Liu Chengyao Zhu |
| author_sort | Huan Liu |
| collection | DOAJ |
| description | ABSTRACT Background Glomus tumors are rare, benign mesenchymal neoplasms predominantly located in subungual regions of the extremities. Their occurrence in the mandibular region is exceptionally uncommon, presenting unique diagnostic challenges. Only a limited number of submandibular glomus tumors have been documented, leaving their presentation and management largely underexplored. Case We presented a case of glomus tumor in the submandibular area of a 60‐year‐old female, which appeared as a purplish‐red lesion. In the absence of characteristic symptoms such as tenderness and cold sensitivity, the lesion was initially misdiagnosed as a pigmented nevus. Histopathological analysis subsequently confirmed the diagnosis as a glomus tumor. Immunohistochemical (IHC) staining further confirmed the tumor's smooth muscle and mesenchymal origins, with positive for Vimentin, SMA, Syn, Actin, Desmin, and CD34. The patient underwent surgical tumor excision with no recurrence after 28 months of follow‐up. Conclusion This case underscores the importance of considering glomus tumors in atypical locations and highlights the need for a comprehensive diagnostic approach to prevent misdiagnosis. Surgical excision remains the primary treatment, with extended postoperative surveillance recommended to monitor for recurrence. |
| format | Article |
| id | doaj-art-f1350054959e431b8acb1336c26097b1 |
| institution | Kabale University |
| issn | 2573-8348 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj-art-f1350054959e431b8acb1336c26097b12025-01-30T15:46:35ZengWileyCancer Reports2573-83482025-01-0181n/an/a10.1002/cnr2.70113Glomus Tumor in the Left Submandibular Region: A Rare Case Report and Literature ReviewHuan Liu0Chengyao Zhu1Department of General Practice Affiliated Hospital of Hangzhou Normal University Hangzhou ChinaDepartment of Dermatology the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University Yiwu ChinaABSTRACT Background Glomus tumors are rare, benign mesenchymal neoplasms predominantly located in subungual regions of the extremities. Their occurrence in the mandibular region is exceptionally uncommon, presenting unique diagnostic challenges. Only a limited number of submandibular glomus tumors have been documented, leaving their presentation and management largely underexplored. Case We presented a case of glomus tumor in the submandibular area of a 60‐year‐old female, which appeared as a purplish‐red lesion. In the absence of characteristic symptoms such as tenderness and cold sensitivity, the lesion was initially misdiagnosed as a pigmented nevus. Histopathological analysis subsequently confirmed the diagnosis as a glomus tumor. Immunohistochemical (IHC) staining further confirmed the tumor's smooth muscle and mesenchymal origins, with positive for Vimentin, SMA, Syn, Actin, Desmin, and CD34. The patient underwent surgical tumor excision with no recurrence after 28 months of follow‐up. Conclusion This case underscores the importance of considering glomus tumors in atypical locations and highlights the need for a comprehensive diagnostic approach to prevent misdiagnosis. Surgical excision remains the primary treatment, with extended postoperative surveillance recommended to monitor for recurrence.https://doi.org/10.1002/cnr2.70113glomus tumorimmunohistochemistrymolecular diagnostics techniquessubmandibular regionsurgical excision |
| spellingShingle | Huan Liu Chengyao Zhu Glomus Tumor in the Left Submandibular Region: A Rare Case Report and Literature Review Cancer Reports glomus tumor immunohistochemistry molecular diagnostics techniques submandibular region surgical excision |
| title | Glomus Tumor in the Left Submandibular Region: A Rare Case Report and Literature Review |
| title_full | Glomus Tumor in the Left Submandibular Region: A Rare Case Report and Literature Review |
| title_fullStr | Glomus Tumor in the Left Submandibular Region: A Rare Case Report and Literature Review |
| title_full_unstemmed | Glomus Tumor in the Left Submandibular Region: A Rare Case Report and Literature Review |
| title_short | Glomus Tumor in the Left Submandibular Region: A Rare Case Report and Literature Review |
| title_sort | glomus tumor in the left submandibular region a rare case report and literature review |
| topic | glomus tumor immunohistochemistry molecular diagnostics techniques submandibular region surgical excision |
| url | https://doi.org/10.1002/cnr2.70113 |
| work_keys_str_mv | AT huanliu glomustumorintheleftsubmandibularregionararecasereportandliteraturereview AT chengyaozhu glomustumorintheleftsubmandibularregionararecasereportandliteraturereview |