Ketamine-associated upper urinary tract dysfunction: What we know from current literature
Objective: To review the current literature on ketamine-associated upper urinary tract (UUT) dysfunction and provide an overview of its pathogenesis and treatment principles. Methods: A literature search was conducted using PubMed and Cochrane databases for relevant articles published in English bet...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Asian Journal of Urology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214388224001188 |
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| author | Zhihuan Zheng Zhongyi Li Jiazhe Yuan Feng Han Li Huang Zhao Wang |
| author_facet | Zhihuan Zheng Zhongyi Li Jiazhe Yuan Feng Han Li Huang Zhao Wang |
| author_sort | Zhihuan Zheng |
| collection | DOAJ |
| description | Objective: To review the current literature on ketamine-associated upper urinary tract (UUT) dysfunction and provide an overview of its pathogenesis and treatment principles. Methods: A literature search was conducted using PubMed and Cochrane databases for relevant articles published in English between 2008 and 2023. Keywords used included “ketamine” and “upper urinary tract”. Results: A total of 22 papers were included. Relatively few studies have focused on ketamine-associated UUT dysfunction. Exclusion criteria included lack of hydronephrosis, or pathological findings. After careful screening and exclusion, we finally adopted 11 of these papers and analyzed them. Ketamine-associated UUT dysfunction may be a concern in this field. Conclusion: Ketamine abuse can lead to UUT impairment and dysfunction, with symptoms such as bladder dysfunction and contracted bladder with vesicoureteral reflux, direct damage and barrier dysfunction, inflammation, apoptosis, fibrosis and stricture, and papillary necrosis. Oxidative stress, autophagy, and microvascular injury are also potential pathogenic mechanisms. The detection of these symptoms largely depends on laboratory and imaging examinations. The treatment principles of ketamine-associated UUT dysfunction are protecting the UUT, improving bladder dysfunction, and resuming normal social life. More investigations are needed to clarify the mechanisms and shed light on the treatment of ketamine-associated UUT damage. |
| format | Article |
| id | doaj-art-f1316c10afe7423a9fe55ab1a4f45ae6 |
| institution | Kabale University |
| issn | 2214-3882 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj-art-f1316c10afe7423a9fe55ab1a4f45ae62025-01-30T05:14:17ZengElsevierAsian Journal of Urology2214-38822025-01-011213342Ketamine-associated upper urinary tract dysfunction: What we know from current literatureZhihuan Zheng0Zhongyi Li1Jiazhe Yuan2Feng Han3Li Huang4Zhao Wang5Department of Urology, Xiangya Hospital, Central South University, Changsha, China; Provincial Laboratory for Diagnosis and Treatment of Genitourinary System Disease, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Urology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Critical Care Medicine, Xiangya Hospital of Central South University, Changsha, China; Corresponding authors. Department of Urology, Xiangya Hospital, Central South University, Changsha, China.Department of Urology, Xiangya Hospital, Central South University, Changsha, China; Provincial Laboratory for Diagnosis and Treatment of Genitourinary System Disease, Changsha, China; Corresponding authors. Department of Urology, Xiangya Hospital, Central South University, Changsha, China.Objective: To review the current literature on ketamine-associated upper urinary tract (UUT) dysfunction and provide an overview of its pathogenesis and treatment principles. Methods: A literature search was conducted using PubMed and Cochrane databases for relevant articles published in English between 2008 and 2023. Keywords used included “ketamine” and “upper urinary tract”. Results: A total of 22 papers were included. Relatively few studies have focused on ketamine-associated UUT dysfunction. Exclusion criteria included lack of hydronephrosis, or pathological findings. After careful screening and exclusion, we finally adopted 11 of these papers and analyzed them. Ketamine-associated UUT dysfunction may be a concern in this field. Conclusion: Ketamine abuse can lead to UUT impairment and dysfunction, with symptoms such as bladder dysfunction and contracted bladder with vesicoureteral reflux, direct damage and barrier dysfunction, inflammation, apoptosis, fibrosis and stricture, and papillary necrosis. Oxidative stress, autophagy, and microvascular injury are also potential pathogenic mechanisms. The detection of these symptoms largely depends on laboratory and imaging examinations. The treatment principles of ketamine-associated UUT dysfunction are protecting the UUT, improving bladder dysfunction, and resuming normal social life. More investigations are needed to clarify the mechanisms and shed light on the treatment of ketamine-associated UUT damage.http://www.sciencedirect.com/science/article/pii/S2214388224001188KetamineUpper urinary tract dysfunctionClinical characteristicPathologic mechanism |
| spellingShingle | Zhihuan Zheng Zhongyi Li Jiazhe Yuan Feng Han Li Huang Zhao Wang Ketamine-associated upper urinary tract dysfunction: What we know from current literature Asian Journal of Urology Ketamine Upper urinary tract dysfunction Clinical characteristic Pathologic mechanism |
| title | Ketamine-associated upper urinary tract dysfunction: What we know from current literature |
| title_full | Ketamine-associated upper urinary tract dysfunction: What we know from current literature |
| title_fullStr | Ketamine-associated upper urinary tract dysfunction: What we know from current literature |
| title_full_unstemmed | Ketamine-associated upper urinary tract dysfunction: What we know from current literature |
| title_short | Ketamine-associated upper urinary tract dysfunction: What we know from current literature |
| title_sort | ketamine associated upper urinary tract dysfunction what we know from current literature |
| topic | Ketamine Upper urinary tract dysfunction Clinical characteristic Pathologic mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2214388224001188 |
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