Clinical Impact of Neutrophil Variation on COVID-19 Complications
<b>Background/Objectives</b>: Corona virus disease 2019 (COVID-19) poses a threat to global public health. The early identification of critical cases is crucial to providing timely treatment to patients. Here, we investigated whether the neutrophil levels could predict COVID-19 complicat...
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MDPI AG
2025-02-01
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| author | Khadija El Azhary Bouchra Ghazi Fadila Kouhen Jalila El Bakkouri Hasna Chamlal Adil El Ghanmi Abdallah Badou |
| author_facet | Khadija El Azhary Bouchra Ghazi Fadila Kouhen Jalila El Bakkouri Hasna Chamlal Adil El Ghanmi Abdallah Badou |
| author_sort | Khadija El Azhary |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: Corona virus disease 2019 (COVID-19) poses a threat to global public health. The early identification of critical cases is crucial to providing timely treatment to patients. Here, we investigated whether the neutrophil levels could predict COVID-19 complications. <b>Methods</b>: We performed a retrospective study of patients with COVID-19, admitted to the Cheikh Khalifa International University Hospital, Casablanca, Morocco. Laboratory test results collected upon admission and during hospitalization were analyzed based on clinical information. <b>Results</b>: Our study revealed that a rise in neutrophil “PNN” levels was associated with respiratory deterioration and intubation. They were positively correlated with the procalcitonin and C-reactive protein levels. Interestingly, PNN (polynuclear neutrophil) levels on day 5 proved to be a better predictor of intubation, acute respiratory distress syndrome (ARDS), and mortality than the initial PNN counts, C-reactive protein, or procalcitonin. Moreover, binary logistic regression with stratified PNN-day 5 data revealed that a PNN level on day 5 > 7.7 (109/L) was an independent risk factor for mortality and ARDS. Finally, the PNN levels on day 5 and proinflammatory cytokine IL-6 were positively correlated. <b>Conclusions</b>: Our data showed that neutrophilia proved to be an excellent predictor of complications and mortality during hospitalization and could be used to improve the management of patients with COVID-19. |
| format | Article |
| id | doaj-art-f12b2953924c446f9131fa0f09fcaf99 |
| institution | DOAJ |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-f12b2953924c446f9131fa0f09fcaf992025-08-20T03:12:20ZengMDPI AGDiagnostics2075-44182025-02-0115445710.3390/diagnostics15040457Clinical Impact of Neutrophil Variation on COVID-19 ComplicationsKhadija El Azhary0Bouchra Ghazi1Fadila Kouhen2Jalila El Bakkouri3Hasna Chamlal4Adil El Ghanmi5Abdallah Badou6Laboratory of Immunogenetics and Human Pathologies, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20250, MoroccoImmunopathology-Immunotherapy-Immunomonitoring Laboratory, Faculty of Medicine, Mohammed VI University of Health and Sciences (UM6SS), Casablanca 82403, MoroccoLaboratory of Neurosciences and Oncogenetics, Neurooncology and Oncogenetic Team, Faculty of Medicine, Mohammed VI University of Health and Sciences (UM6SS), Casablanca 82403, MoroccoImmunopathology-Immunotherapy-Immunomonitoring Laboratory, Faculty of Medicine, Mohammed VI University of Health and Sciences (UM6SS), Casablanca 82403, MoroccoComputer Science and Systems Laboratory (LIS), Faculty of Sciences Ain Chock, Hassan II University of Casablanca, Casablanca 20250, MoroccoImmunopathology-Immunotherapy-Immunomonitoring Laboratory, Faculty of Medicine, Mohammed VI University of Health and Sciences (UM6SS), Casablanca 82403, MoroccoLaboratory of Immunogenetics and Human Pathologies, Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca 20250, Morocco<b>Background/Objectives</b>: Corona virus disease 2019 (COVID-19) poses a threat to global public health. The early identification of critical cases is crucial to providing timely treatment to patients. Here, we investigated whether the neutrophil levels could predict COVID-19 complications. <b>Methods</b>: We performed a retrospective study of patients with COVID-19, admitted to the Cheikh Khalifa International University Hospital, Casablanca, Morocco. Laboratory test results collected upon admission and during hospitalization were analyzed based on clinical information. <b>Results</b>: Our study revealed that a rise in neutrophil “PNN” levels was associated with respiratory deterioration and intubation. They were positively correlated with the procalcitonin and C-reactive protein levels. Interestingly, PNN (polynuclear neutrophil) levels on day 5 proved to be a better predictor of intubation, acute respiratory distress syndrome (ARDS), and mortality than the initial PNN counts, C-reactive protein, or procalcitonin. Moreover, binary logistic regression with stratified PNN-day 5 data revealed that a PNN level on day 5 > 7.7 (109/L) was an independent risk factor for mortality and ARDS. Finally, the PNN levels on day 5 and proinflammatory cytokine IL-6 were positively correlated. <b>Conclusions</b>: Our data showed that neutrophilia proved to be an excellent predictor of complications and mortality during hospitalization and could be used to improve the management of patients with COVID-19.https://www.mdpi.com/2075-4418/15/4/457neutrophilSARS-CoV-2complicationmortalitypredictionpatients with COVID-19 |
| spellingShingle | Khadija El Azhary Bouchra Ghazi Fadila Kouhen Jalila El Bakkouri Hasna Chamlal Adil El Ghanmi Abdallah Badou Clinical Impact of Neutrophil Variation on COVID-19 Complications Diagnostics neutrophil SARS-CoV-2 complication mortality prediction patients with COVID-19 |
| title | Clinical Impact of Neutrophil Variation on COVID-19 Complications |
| title_full | Clinical Impact of Neutrophil Variation on COVID-19 Complications |
| title_fullStr | Clinical Impact of Neutrophil Variation on COVID-19 Complications |
| title_full_unstemmed | Clinical Impact of Neutrophil Variation on COVID-19 Complications |
| title_short | Clinical Impact of Neutrophil Variation on COVID-19 Complications |
| title_sort | clinical impact of neutrophil variation on covid 19 complications |
| topic | neutrophil SARS-CoV-2 complication mortality prediction patients with COVID-19 |
| url | https://www.mdpi.com/2075-4418/15/4/457 |
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