Histone lactylation-induced premature senescence contributes to 1-nitropyrene-Induced chronic obstructive pulmonary disease

Our previous study revealed that mice exposed to 1-nitropyrene (1-NP) develop pulmonary fibrosis and senescent alveolar cells. However, the impacts of chronic 1-NP on chronic obstructive pulmonary disease (COPD) and the underlying mechanism are unclear. Our research suggested that chronic 1-NP evoke...

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Bibliographic Details
Main Authors: Rong-Rong Wang, Dan-Lei Chen, Meng Wei, Se-Ruo Li, Peng Zhou, Jing Sun, Qi-Yuan He, Jin Yang, Hui Zhao, Lin Fu
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Redox Biology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002162
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