Body position influence on cerebrospinal fluid volume redistribution inside the cranial and spinal CSF compartments
IntroductionIt is generally accepted that during body position changes from horizontal to vertical there is a short-lasting shift of a certain CSF volume from the cranium into the hydrostatically lower parts of the spinal space, which leads to transitory CSF pressure decrease to negative values.Meth...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2024.1463740/full |
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| author | I. Strbačko M. Radoš I. Jurjević D. Orešković M. Klarica M. Klarica |
| author_facet | I. Strbačko M. Radoš I. Jurjević D. Orešković M. Klarica M. Klarica |
| author_sort | I. Strbačko |
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| description | IntroductionIt is generally accepted that during body position changes from horizontal to vertical there is a short-lasting shift of a certain CSF volume from the cranium into the hydrostatically lower parts of the spinal space, which leads to transitory CSF pressure decrease to negative values.MethodsIn order to test this, we performed MRI volumetry of cranial and spinal part of the CSF space in healthy volunteers of both genders (n = 22) in three different body positions [horizontal (H); elevated head and upper body (H-UP) under an angle about 30° from the base; elevated lower body (B-UP) under an angle about 30° from the base].ResultsVolumes of brain and spinal cord tissue did not change during body position changes. Significant CSF volume (ml) changes occur inside the spinal space in the tested body positions, primarily in the lumbosacral segment (H-UP – 38.1 ± 7.0; H – 34.4 ± 6.5; B-UP – 28.7 ± 6.5), while at the same time no significant CSF volume changes have been observed inside the cranium in two tested positions (H and B-UP) in which it was possible to measure intracranial CSF volume changes or if we sum up cervical and cranial CSF volumes in those positions.ConclusionObserved results suggest that during the changes of body position CSF volume redistribution occurs, primarily inside the spinal and not the cranial space. This is in accordance with the new hypothesis by which spinal intradural space can significantly change its volume due to its elasticity, thus adjusting to the influence of gravity and pressure changes. |
| format | Article |
| id | doaj-art-f124aa03a2934722aab4b9055a4b77a1 |
| institution | Kabale University |
| issn | 1662-5161 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj-art-f124aa03a2934722aab4b9055a4b77a12025-01-29T06:45:56ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612025-01-011810.3389/fnhum.2024.14637401463740Body position influence on cerebrospinal fluid volume redistribution inside the cranial and spinal CSF compartmentsI. Strbačko0M. Radoš1I. Jurjević2D. Orešković3M. Klarica4M. Klarica5Croatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, CroatiaCroatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, CroatiaDepartment of Neurology, University Hospital Centre Zagreb, Zagreb, CroatiaDepartment of Molecular Biology, Ruđer Bošković Institute, Zagreb, CroatiaCroatian Institute for Brain Research, School of Medicine, University of Zagreb, Zagreb, CroatiaDepartment of Pharmacology, School of Medicine, University of Zagreb, Zagreb, CroatiaIntroductionIt is generally accepted that during body position changes from horizontal to vertical there is a short-lasting shift of a certain CSF volume from the cranium into the hydrostatically lower parts of the spinal space, which leads to transitory CSF pressure decrease to negative values.MethodsIn order to test this, we performed MRI volumetry of cranial and spinal part of the CSF space in healthy volunteers of both genders (n = 22) in three different body positions [horizontal (H); elevated head and upper body (H-UP) under an angle about 30° from the base; elevated lower body (B-UP) under an angle about 30° from the base].ResultsVolumes of brain and spinal cord tissue did not change during body position changes. Significant CSF volume (ml) changes occur inside the spinal space in the tested body positions, primarily in the lumbosacral segment (H-UP – 38.1 ± 7.0; H – 34.4 ± 6.5; B-UP – 28.7 ± 6.5), while at the same time no significant CSF volume changes have been observed inside the cranium in two tested positions (H and B-UP) in which it was possible to measure intracranial CSF volume changes or if we sum up cervical and cranial CSF volumes in those positions.ConclusionObserved results suggest that during the changes of body position CSF volume redistribution occurs, primarily inside the spinal and not the cranial space. This is in accordance with the new hypothesis by which spinal intradural space can significantly change its volume due to its elasticity, thus adjusting to the influence of gravity and pressure changes.https://www.frontiersin.org/articles/10.3389/fnhum.2024.1463740/fullcranial CSF volumespinal CSF volumebody positionvolume redistributionsegmentationMR volumetry |
| spellingShingle | I. Strbačko M. Radoš I. Jurjević D. Orešković M. Klarica M. Klarica Body position influence on cerebrospinal fluid volume redistribution inside the cranial and spinal CSF compartments Frontiers in Human Neuroscience cranial CSF volume spinal CSF volume body position volume redistribution segmentation MR volumetry |
| title | Body position influence on cerebrospinal fluid volume redistribution inside the cranial and spinal CSF compartments |
| title_full | Body position influence on cerebrospinal fluid volume redistribution inside the cranial and spinal CSF compartments |
| title_fullStr | Body position influence on cerebrospinal fluid volume redistribution inside the cranial and spinal CSF compartments |
| title_full_unstemmed | Body position influence on cerebrospinal fluid volume redistribution inside the cranial and spinal CSF compartments |
| title_short | Body position influence on cerebrospinal fluid volume redistribution inside the cranial and spinal CSF compartments |
| title_sort | body position influence on cerebrospinal fluid volume redistribution inside the cranial and spinal csf compartments |
| topic | cranial CSF volume spinal CSF volume body position volume redistribution segmentation MR volumetry |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2024.1463740/full |
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