Role of Vitamin D in the Prevention of Pancreatic Cancer
Pancreatic cancer is a malignancy of poor prognosis which is mostly diagnosed at advanced stages. Current treatment modalities are very limited creating great interest for novel preventive and therapeutic options. Vitamin D seems to have a protective effect against pancreatic cancer by participating...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2010/721365 |
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| author | Pubudu Bulathsinghala Kostas N. Syrigos Muhammad W. Saif |
| author_facet | Pubudu Bulathsinghala Kostas N. Syrigos Muhammad W. Saif |
| author_sort | Pubudu Bulathsinghala |
| collection | DOAJ |
| description | Pancreatic cancer is a malignancy of poor prognosis which is mostly diagnosed at advanced stages. Current treatment modalities are very limited creating great interest for novel preventive and therapeutic options. Vitamin D seems to have a protective effect against pancreatic cancer by participating in numerous proapoptotic, antiangiogenic, anti-inflammatory, prodifferentiating, and immunomodulating mechanisms. 25-hydroxyvitamin D [25(OH)D] serum concentrations are currently the best indicator of vitamin D status. There are three main sources of vitamin D: sun exposure, diet,and dietary supplements. Sun exposure has been associated with lower incidence of pancreatic cancer in ecological studies. Increased vitamin D levels seem to protect against pancreatic cancer, but caution is needed as excessive dietary intake may have opposite results. Future studies will verify the role of vitamin D in the prevention and therapy of pancreatic cancer and will lead to guidelines on adequate sun exposure and vitamin D dietary intake. |
| format | Article |
| id | doaj-art-f0f4deeda11d4ce9ad6efbdff2380663 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-f0f4deeda11d4ce9ad6efbdff23806632025-02-03T06:06:14ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322010-01-01201010.1155/2010/721365721365Role of Vitamin D in the Prevention of Pancreatic CancerPubudu Bulathsinghala0Kostas N. Syrigos1Muhammad W. Saif2Department of Internal Medicine, Danbury Hospital, 24 Hospital Avenue, Danbury, CT 06810, USAOncology Unit, 3rd Department of Medicine, Sotiria General Hospital, Athens School of Medicine, Mesogion 152, 11527 Athens, GreeceGI Oncology Section of the Division of Hematology/Oncology, Herbert Irving Comprehensive Cancer Center, Milstein Hospital, Clinical Medicine, Columbia University College of Physicians and Surgeons, Suite 6-435, 177 Fort Washington Avenue, NY 10032, USAPancreatic cancer is a malignancy of poor prognosis which is mostly diagnosed at advanced stages. Current treatment modalities are very limited creating great interest for novel preventive and therapeutic options. Vitamin D seems to have a protective effect against pancreatic cancer by participating in numerous proapoptotic, antiangiogenic, anti-inflammatory, prodifferentiating, and immunomodulating mechanisms. 25-hydroxyvitamin D [25(OH)D] serum concentrations are currently the best indicator of vitamin D status. There are three main sources of vitamin D: sun exposure, diet,and dietary supplements. Sun exposure has been associated with lower incidence of pancreatic cancer in ecological studies. Increased vitamin D levels seem to protect against pancreatic cancer, but caution is needed as excessive dietary intake may have opposite results. Future studies will verify the role of vitamin D in the prevention and therapy of pancreatic cancer and will lead to guidelines on adequate sun exposure and vitamin D dietary intake.http://dx.doi.org/10.1155/2010/721365 |
| spellingShingle | Pubudu Bulathsinghala Kostas N. Syrigos Muhammad W. Saif Role of Vitamin D in the Prevention of Pancreatic Cancer Journal of Nutrition and Metabolism |
| title | Role of Vitamin D in the Prevention of Pancreatic Cancer |
| title_full | Role of Vitamin D in the Prevention of Pancreatic Cancer |
| title_fullStr | Role of Vitamin D in the Prevention of Pancreatic Cancer |
| title_full_unstemmed | Role of Vitamin D in the Prevention of Pancreatic Cancer |
| title_short | Role of Vitamin D in the Prevention of Pancreatic Cancer |
| title_sort | role of vitamin d in the prevention of pancreatic cancer |
| url | http://dx.doi.org/10.1155/2010/721365 |
| work_keys_str_mv | AT pubudubulathsinghala roleofvitamindinthepreventionofpancreaticcancer AT kostasnsyrigos roleofvitamindinthepreventionofpancreaticcancer AT muhammadwsaif roleofvitamindinthepreventionofpancreaticcancer |