Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer

Selective Activation of Cancer Stem Cells by Size-Specific Hyaluronan in Head and Neck Cancer

We determined that human head and neck cancer cells (HSC-3 cell line) contain a subpopulation displaying cancer stem cell (CSC) properties and are very tumorigenic. Specifically, we investigated whether different sizes of hyaluronan (HA) (e.g., 5 kDa, 20 kDa, 200 kDa, or 700 kDa-HA-sizes) play a rol...

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Bibliographic Details
Main Authors: Marisa Shiina, Lilly Y. W. Bourguignon
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:International Journal of Cell Biology
Online Access:http://dx.doi.org/10.1155/2015/989070
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