Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer
The role of hyaluronan (HA), serum-derived HA-associated protein (SHAP)-HA complex and hyaluronan synthase (HAS) in endometrial carcinomas was investigated. The relationship of metalloproteinase (MMP) and its inhibitor (TIMP) with HA and the SHAP-HA complex was also examined. The expression of HAS1...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2011/739150 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832563882416144384 |
|---|---|
| author | Hiromitsu Yabushita Keita Iwasaki Kouhei Kanyama Yukihiko Obayashi Lisheng Zhuo Naoki Itano Koji Kimata Akihiko Wakatsuki |
| author_facet | Hiromitsu Yabushita Keita Iwasaki Kouhei Kanyama Yukihiko Obayashi Lisheng Zhuo Naoki Itano Koji Kimata Akihiko Wakatsuki |
| author_sort | Hiromitsu Yabushita |
| collection | DOAJ |
| description | The role of hyaluronan (HA), serum-derived HA-associated protein (SHAP)-HA complex and hyaluronan synthase (HAS) in endometrial carcinomas was investigated. The relationship of metalloproteinase (MMP) and its inhibitor (TIMP) with HA and the SHAP-HA complex was also examined. The expression of HAS1 was related to the depth of myometrial invasion and lymph-vascular space involvement. The serum levels of HA, SHAP-HA complex, MMP-9, and TIMP-1 were increased in related with the depth of myometrial invasion, histological grade and lymph-vascular space involvement. They were also higher in the HAS1-positive group compared to -negative group. The serum concentrations of HA and SHAP-HA complex had a significant correlation with the MMP-9 and TIMP-1. The patients with elevated SHAP-HA complex had the shorter disease-free survival. The multivariate analysis revealed that the SHAP-HA complex was the independent variable for disease-free survival of endometrial cancer patients. In conclusion, the elevation of serum SHAP-HA complex depended on the HAS1 expression and the SHAP-HA complex is a useful marker to predict disease recurrence in endometrial cancer patients. The SHAP-HA complex may promote the lymph-vascular space involvement and the synthesis and activation of MMP-9 and TIMP-1 in the progression of endometrial cancer. |
| format | Article |
| id | doaj-art-f0ee17a217574502a314b07becf56fee |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-f0ee17a217574502a314b07becf56fee2025-02-03T01:12:25ZengWileyObstetrics and Gynecology International1687-95891687-95972011-01-01201110.1155/2011/739150739150Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial CancerHiromitsu Yabushita0Keita Iwasaki1Kouhei Kanyama2Yukihiko Obayashi3Lisheng Zhuo4Naoki Itano5Koji Kimata6Akihiko Wakatsuki7Department of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute-cho, Aichi 480-1195, JapanDepartment of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute-cho, Aichi 480-1195, JapanDepartment of Obstetrics and Gynecology, Toyokawa City Hospital, Toyakawa, Aichi 422-8561, JapanDepartment of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute-cho, Aichi 480-1195, JapanResearch Complex for the Medicine Frontiers, School of Medicine, Aichi Medical University, Nagakute-cho, Aichi 480-1195, JapanDepartment of Molecular Biosciences, Faculty of Life Sciences, Kyoto Sangyo University, Motoyama, Kamigamo, Kita-ku, Kyoto 603-8555, JapanResearch Complex for the Medicine Frontiers, School of Medicine, Aichi Medical University, Nagakute-cho, Aichi 480-1195, JapanDepartment of Obstetrics and Gynecology, School of Medicine, Aichi Medical University, Nagakute-cho, Aichi 480-1195, JapanThe role of hyaluronan (HA), serum-derived HA-associated protein (SHAP)-HA complex and hyaluronan synthase (HAS) in endometrial carcinomas was investigated. The relationship of metalloproteinase (MMP) and its inhibitor (TIMP) with HA and the SHAP-HA complex was also examined. The expression of HAS1 was related to the depth of myometrial invasion and lymph-vascular space involvement. The serum levels of HA, SHAP-HA complex, MMP-9, and TIMP-1 were increased in related with the depth of myometrial invasion, histological grade and lymph-vascular space involvement. They were also higher in the HAS1-positive group compared to -negative group. The serum concentrations of HA and SHAP-HA complex had a significant correlation with the MMP-9 and TIMP-1. The patients with elevated SHAP-HA complex had the shorter disease-free survival. The multivariate analysis revealed that the SHAP-HA complex was the independent variable for disease-free survival of endometrial cancer patients. In conclusion, the elevation of serum SHAP-HA complex depended on the HAS1 expression and the SHAP-HA complex is a useful marker to predict disease recurrence in endometrial cancer patients. The SHAP-HA complex may promote the lymph-vascular space involvement and the synthesis and activation of MMP-9 and TIMP-1 in the progression of endometrial cancer.http://dx.doi.org/10.1155/2011/739150 |
| spellingShingle | Hiromitsu Yabushita Keita Iwasaki Kouhei Kanyama Yukihiko Obayashi Lisheng Zhuo Naoki Itano Koji Kimata Akihiko Wakatsuki Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer Obstetrics and Gynecology International |
| title | Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer |
| title_full | Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer |
| title_fullStr | Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer |
| title_full_unstemmed | Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer |
| title_short | Clinicopathological Role of Serum-Derived Hyaluronan-Associated Protein (SHAP)-Hyaluronan Complex in Endometrial Cancer |
| title_sort | clinicopathological role of serum derived hyaluronan associated protein shap hyaluronan complex in endometrial cancer |
| url | http://dx.doi.org/10.1155/2011/739150 |
| work_keys_str_mv | AT hiromitsuyabushita clinicopathologicalroleofserumderivedhyaluronanassociatedproteinshaphyaluronancomplexinendometrialcancer AT keitaiwasaki clinicopathologicalroleofserumderivedhyaluronanassociatedproteinshaphyaluronancomplexinendometrialcancer AT kouheikanyama clinicopathologicalroleofserumderivedhyaluronanassociatedproteinshaphyaluronancomplexinendometrialcancer AT yukihikoobayashi clinicopathologicalroleofserumderivedhyaluronanassociatedproteinshaphyaluronancomplexinendometrialcancer AT lishengzhuo clinicopathologicalroleofserumderivedhyaluronanassociatedproteinshaphyaluronancomplexinendometrialcancer AT naokiitano clinicopathologicalroleofserumderivedhyaluronanassociatedproteinshaphyaluronancomplexinendometrialcancer AT kojikimata clinicopathologicalroleofserumderivedhyaluronanassociatedproteinshaphyaluronancomplexinendometrialcancer AT akihikowakatsuki clinicopathologicalroleofserumderivedhyaluronanassociatedproteinshaphyaluronancomplexinendometrialcancer |