Structural MRI study of Pareidolia and Visual Hallucinations in Drug–Naïve Parkinson’s disease
Abstract Visual hallucinations (VH) and pareidolia, a type of minor hallucination, share common underlying mechanisms. However, the similarities and differences in their brain regions remain poorly understood in Parkinson’s disease (PD). A total of 104 drug-naïve PD patients underwent structural MRI...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-82707-x |
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| author | Masakazu Ozawa Tomotaka Shiraishi Hidetomo Murakami Daisuke Yoshimaru Asako Onda Hiromasa Matsuno Teppei Komatsu Kenichi Sakuta Kenichiro Sakai Tadashi Umehara Hidetaka Mitsumura Hirotaka James Okano Yasuyuki Iguchi |
| author_facet | Masakazu Ozawa Tomotaka Shiraishi Hidetomo Murakami Daisuke Yoshimaru Asako Onda Hiromasa Matsuno Teppei Komatsu Kenichi Sakuta Kenichiro Sakai Tadashi Umehara Hidetaka Mitsumura Hirotaka James Okano Yasuyuki Iguchi |
| author_sort | Masakazu Ozawa |
| collection | DOAJ |
| description | Abstract Visual hallucinations (VH) and pareidolia, a type of minor hallucination, share common underlying mechanisms. However, the similarities and differences in their brain regions remain poorly understood in Parkinson’s disease (PD). A total of 104 drug-naïve PD patients underwent structural MRI and were assessed for pareidolia using the Noise Pareidolia Test (NPT) were enrolled. Subcortical gray matter volume and cortical surface volume were analyzed using the FreeSurfer software. Structural analyses revealed associations between NPT scores and atrophy in the right thalamus, right hippocampus, right temporal cortex, and right orbitofrontal cortex in all PD participants. These results were almost the same after adjusting for right-handed 97 patients with PD. It is considered that hallucinations in patients with PD are related to altered integration of sensory input (bottom-up) and prior knowledge (top-down) within the visual system. Our findings indicate that pareidolia in PD involves both bottom-up (thalamus and temporal cortex) and top-down (orbitofrontal cortex) processing disturbances; in contrast, VH predominantly involves bottom-up but not top-down regions. Understanding these distinctions could aid in the development of targeted interventions for hallucinations in patients with PD. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-f0ed454b75a442068c84f326987074bf2025-08-20T02:43:36ZengNature PortfolioScientific Reports2045-23222024-12-011411810.1038/s41598-024-82707-xStructural MRI study of Pareidolia and Visual Hallucinations in Drug–Naïve Parkinson’s diseaseMasakazu Ozawa0Tomotaka Shiraishi1Hidetomo Murakami2Daisuke Yoshimaru3Asako Onda4Hiromasa Matsuno5Teppei Komatsu6Kenichi Sakuta7Kenichiro Sakai8Tadashi Umehara9Hidetaka Mitsumura10Hirotaka James Okano11Yasuyuki Iguchi12Department of Neurology, The Jikei University School of MedicineDepartment of Neurology, The Jikei University School of MedicineDepartment of Neurology, The Jikei University School of MedicineDivision of Regenerative Medicine, The Jikei University School of MedicineDepartment of Neurology, The Jikei University School of MedicineDepartment of Neurology, The Jikei University School of MedicineDepartment of Neurology, The Jikei University School of MedicineDepartment of Neurology, The Jikei University School of MedicineDepartment of Neurology, The Jikei University School of MedicineDepartment of Neurology, The Jikei University School of MedicineDepartment of Neurology, The Jikei University School of MedicineDivision of Regenerative Medicine, The Jikei University School of MedicineDepartment of Neurology, The Jikei University School of MedicineAbstract Visual hallucinations (VH) and pareidolia, a type of minor hallucination, share common underlying mechanisms. However, the similarities and differences in their brain regions remain poorly understood in Parkinson’s disease (PD). A total of 104 drug-naïve PD patients underwent structural MRI and were assessed for pareidolia using the Noise Pareidolia Test (NPT) were enrolled. Subcortical gray matter volume and cortical surface volume were analyzed using the FreeSurfer software. Structural analyses revealed associations between NPT scores and atrophy in the right thalamus, right hippocampus, right temporal cortex, and right orbitofrontal cortex in all PD participants. These results were almost the same after adjusting for right-handed 97 patients with PD. It is considered that hallucinations in patients with PD are related to altered integration of sensory input (bottom-up) and prior knowledge (top-down) within the visual system. Our findings indicate that pareidolia in PD involves both bottom-up (thalamus and temporal cortex) and top-down (orbitofrontal cortex) processing disturbances; in contrast, VH predominantly involves bottom-up but not top-down regions. Understanding these distinctions could aid in the development of targeted interventions for hallucinations in patients with PD.https://doi.org/10.1038/s41598-024-82707-xPareidoliaVisual hallucinationMinor hallucinationParkinson’s diseaseSurface-based morphometry |
| spellingShingle | Masakazu Ozawa Tomotaka Shiraishi Hidetomo Murakami Daisuke Yoshimaru Asako Onda Hiromasa Matsuno Teppei Komatsu Kenichi Sakuta Kenichiro Sakai Tadashi Umehara Hidetaka Mitsumura Hirotaka James Okano Yasuyuki Iguchi Structural MRI study of Pareidolia and Visual Hallucinations in Drug–Naïve Parkinson’s disease Scientific Reports Pareidolia Visual hallucination Minor hallucination Parkinson’s disease Surface-based morphometry |
| title | Structural MRI study of Pareidolia and Visual Hallucinations in Drug–Naïve Parkinson’s disease |
| title_full | Structural MRI study of Pareidolia and Visual Hallucinations in Drug–Naïve Parkinson’s disease |
| title_fullStr | Structural MRI study of Pareidolia and Visual Hallucinations in Drug–Naïve Parkinson’s disease |
| title_full_unstemmed | Structural MRI study of Pareidolia and Visual Hallucinations in Drug–Naïve Parkinson’s disease |
| title_short | Structural MRI study of Pareidolia and Visual Hallucinations in Drug–Naïve Parkinson’s disease |
| title_sort | structural mri study of pareidolia and visual hallucinations in drug naive parkinson s disease |
| topic | Pareidolia Visual hallucination Minor hallucination Parkinson’s disease Surface-based morphometry |
| url | https://doi.org/10.1038/s41598-024-82707-x |
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