SARS-CoV-2 mRNA vaccines confer protection in diet-induced obese mice despite altered immune cell profiles in the lung

SARS-CoV-2 mRNA vaccines confer protection in diet-induced obese mice despite altered immune cell profiles in the lung

Abstract Hypertension, diabetes, and obesity are comorbidities that influence severe cases of COVID-19 and are associated with weak humoral immunity after vaccination. We hypothesized that the diet-induced obese (DIO) K18-hACE2 mouse model could be utilized to reveal sex and DIO- specific difference...

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Bibliographic Details
Main Authors: Katherine S. Lee, Dylan T. Boehm, Olivia A. Miller-Stump, Nathaniel A. Rader, Melissa Cooper, Holly A. Cyphert, Emel Sen-Kilic, Mariette Barbier, F. Heath Damron
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
SARS-CoV-2
COVID-19
Diabetes
Obesity
K18-hACE2 transgenic mouse
Omicron variant
Online Access:https://doi.org/10.1038/s41598-025-12320-z
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