Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson’s Patients
We used EEG source analysis to identify which cortical areas were involved in the automatic and controlled processes of inhibitory control on a flanker task and compared the potential efficacy of recombinant-human erythropoietin (rHuEPO) on the performance of Parkinson’s Disease patients. The sample...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2020/8625794 |
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| author | Maria L. Bringas Vega Shengnan Liu Min Zhang Ivonne Pedroso Ibañez Lilia M. Morales Chacon Lidice Galan Garcia Vanessa Perez Bocourt Marjan Jahanshahi Pedro A. Valdes-Sosa |
| author_facet | Maria L. Bringas Vega Shengnan Liu Min Zhang Ivonne Pedroso Ibañez Lilia M. Morales Chacon Lidice Galan Garcia Vanessa Perez Bocourt Marjan Jahanshahi Pedro A. Valdes-Sosa |
| author_sort | Maria L. Bringas Vega |
| collection | DOAJ |
| description | We used EEG source analysis to identify which cortical areas were involved in the automatic and controlled processes of inhibitory control on a flanker task and compared the potential efficacy of recombinant-human erythropoietin (rHuEPO) on the performance of Parkinson’s Disease patients. The samples were 18 medicated PD patients (nine of them received rHuEPO in addition to their usual anti-PD medication through random allocation and the other nine patients were on their regular anti-PD medication only) and 9 age and education-matched healthy controls (HCs) who completed the flanker task with simultaneous EEG recordings. N1 and N2 event-related potential (ERP) components were identified and a low resolution tomography (LORETA) inverse solution was employed to localize the neural generators. Reaction times and errors were increased for the incongruent flankers for PD patients compared to controls. EEG source analysis identified an effect of rHuEPO on the lingual gyri for the early N1 component. N2-related sources in middle cingulate and precuneus were associated with the inhibition of automatic responses evoked by incongruent stimuli differentiated PD and HCs. From our results rHuEPO seems to mediate an effect on N1 sources in lingual gyri but not on behavioural performance. N2-related sources in middle cingulate and precuneus were evoked by incongruent stimuli differentiated PD and HCs. |
| format | Article |
| id | doaj-art-f0dcf79eb0724fbabed78b1dfd402f0e |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-f0dcf79eb0724fbabed78b1dfd402f0e2025-02-03T06:44:57ZengWileyParkinson's Disease2090-80832042-00802020-01-01202010.1155/2020/86257948625794Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson’s PatientsMaria L. Bringas Vega0Shengnan Liu1Min Zhang2Ivonne Pedroso Ibañez3Lilia M. Morales Chacon4Lidice Galan Garcia5Vanessa Perez Bocourt6Marjan Jahanshahi7Pedro A. Valdes-Sosa8The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaCentro Internacional de Restauracion Neurologica CIREN, La Habana, CubaCentro Internacional de Restauracion Neurologica CIREN, La Habana, CubaCentro de Neurociencias de Cuba CNEURO, La Habana, CubaMiami Dade College, Miami, FL, USAThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, ChinaWe used EEG source analysis to identify which cortical areas were involved in the automatic and controlled processes of inhibitory control on a flanker task and compared the potential efficacy of recombinant-human erythropoietin (rHuEPO) on the performance of Parkinson’s Disease patients. The samples were 18 medicated PD patients (nine of them received rHuEPO in addition to their usual anti-PD medication through random allocation and the other nine patients were on their regular anti-PD medication only) and 9 age and education-matched healthy controls (HCs) who completed the flanker task with simultaneous EEG recordings. N1 and N2 event-related potential (ERP) components were identified and a low resolution tomography (LORETA) inverse solution was employed to localize the neural generators. Reaction times and errors were increased for the incongruent flankers for PD patients compared to controls. EEG source analysis identified an effect of rHuEPO on the lingual gyri for the early N1 component. N2-related sources in middle cingulate and precuneus were associated with the inhibition of automatic responses evoked by incongruent stimuli differentiated PD and HCs. From our results rHuEPO seems to mediate an effect on N1 sources in lingual gyri but not on behavioural performance. N2-related sources in middle cingulate and precuneus were evoked by incongruent stimuli differentiated PD and HCs.http://dx.doi.org/10.1155/2020/8625794 |
| spellingShingle | Maria L. Bringas Vega Shengnan Liu Min Zhang Ivonne Pedroso Ibañez Lilia M. Morales Chacon Lidice Galan Garcia Vanessa Perez Bocourt Marjan Jahanshahi Pedro A. Valdes-Sosa Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson’s Patients Parkinson's Disease |
| title | Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson’s Patients |
| title_full | Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson’s Patients |
| title_fullStr | Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson’s Patients |
| title_full_unstemmed | Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson’s Patients |
| title_short | Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson’s Patients |
| title_sort | flanker task elicited event related potential sources reflect human recombinant erythropoietin differential effects on parkinson s patients |
| url | http://dx.doi.org/10.1155/2020/8625794 |
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