The Role of Liver Biopsy in the Management of Patients with Liver Disease

The role of liver biopsy in the diagnosis and management of liver disease is a controversial issue even among hepatologists. Although most causes of elevated liver enzymes can be determined, or at least suspected, on the basis of a careful history and laboratory tests, histological assessment remain...

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Main Author: Florence Wong
Format: Article
Language:English
Published: Wiley 2003-01-01
Series:Canadian Journal of Gastroenterology
Online Access:http://dx.doi.org/10.1155/2003/837069
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author Florence Wong
author_facet Florence Wong
author_sort Florence Wong
collection DOAJ
description The role of liver biopsy in the diagnosis and management of liver disease is a controversial issue even among hepatologists. Although most causes of elevated liver enzymes can be determined, or at least suspected, on the basis of a careful history and laboratory tests, histological assessment remains the gold standard for most liver diseases. Histological evaluation can either confirm or refute clinical diagnoses and can provide information about the severity and stage of disease. Occasionally, the liver biopsy also provides an additional diagnosis. The spectrum of nonalcoholic fatty liver disease accounts for a substantial proportion of cases of chronically elevated liver enzymes and can be reliably diagnosed only by liver biopsy. Prognostic information can be obtained in patients with this disorder, as well as in those with alcoholic liver disease and viral hepatitis, and liver biopsy can be used as a guide to their management.
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spelling doaj-art-f0d8b51f59b9492780bbab4681fe34ed2025-02-03T01:12:14ZengWileyCanadian Journal of Gastroenterology0835-79002003-01-01171165165410.1155/2003/837069The Role of Liver Biopsy in the Management of Patients with Liver DiseaseFlorence Wong0Division of Gastroenterology, Department of Medicine, Toronto General Hospital, University of Toronto, Ontario, CanadaThe role of liver biopsy in the diagnosis and management of liver disease is a controversial issue even among hepatologists. Although most causes of elevated liver enzymes can be determined, or at least suspected, on the basis of a careful history and laboratory tests, histological assessment remains the gold standard for most liver diseases. Histological evaluation can either confirm or refute clinical diagnoses and can provide information about the severity and stage of disease. Occasionally, the liver biopsy also provides an additional diagnosis. The spectrum of nonalcoholic fatty liver disease accounts for a substantial proportion of cases of chronically elevated liver enzymes and can be reliably diagnosed only by liver biopsy. Prognostic information can be obtained in patients with this disorder, as well as in those with alcoholic liver disease and viral hepatitis, and liver biopsy can be used as a guide to their management.http://dx.doi.org/10.1155/2003/837069
spellingShingle Florence Wong
The Role of Liver Biopsy in the Management of Patients with Liver Disease
Canadian Journal of Gastroenterology
title The Role of Liver Biopsy in the Management of Patients with Liver Disease
title_full The Role of Liver Biopsy in the Management of Patients with Liver Disease
title_fullStr The Role of Liver Biopsy in the Management of Patients with Liver Disease
title_full_unstemmed The Role of Liver Biopsy in the Management of Patients with Liver Disease
title_short The Role of Liver Biopsy in the Management of Patients with Liver Disease
title_sort role of liver biopsy in the management of patients with liver disease
url http://dx.doi.org/10.1155/2003/837069
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