Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications
Autogenous bone grafting remains a gold standard for the reconstruction critical-sized bone defects in the craniomaxillofacial region. Nevertheless, this graft procedure has several disadvantages such as restricted availability, donor-site morbidity, and limitations in regard to fully restoring the...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/863157 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566864660660224 |
|---|---|
| author | Yukihiko Kinoshita Hatsuhiko Maeda |
| author_facet | Yukihiko Kinoshita Hatsuhiko Maeda |
| author_sort | Yukihiko Kinoshita |
| collection | DOAJ |
| description | Autogenous bone grafting remains a gold standard for the reconstruction critical-sized bone defects in the craniomaxillofacial region. Nevertheless, this graft procedure has several disadvantages such as restricted availability, donor-site morbidity, and limitations in regard to fully restoring the complicated three-dimensional structures in the craniomaxillofacial bone. The ultimate goal of craniomaxillofacial bone reconstruction is the regeneration of the physiological bone that simultaneously fulfills both morphological and functional restorations. Developments of tissue engineering in the last two decades have brought such a goal closer to reality. In bone tissue engineering, the scaffolds are fundamental, elemental and mesenchymal stem cells/osteoprogenitor cells and bioactive factors. A variety of scaffolds have been developed and used as spacemakers, biodegradable bone substitutes for transplanting to the new bone, matrices of drug delivery system, or supporting structures enhancing adhesion, proliferation, and matrix production of seeded cells according to the circumstances of the bone defects. However, scaffolds to be clinically completely satisfied have not been developed yet. Development of more functional scaffolds is required to be applied widely to cranio-maxillofacial bone defects. This paper reviews recent trends of scaffolds for crania-maxillofacial bone tissue engineering, including our studies. |
| format | Article |
| id | doaj-art-f0cb9a402ced4ff4a6cac93e301df2b5 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-f0cb9a402ced4ff4a6cac93e301df2b52025-02-03T01:03:08ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/863157863157Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering ApplicationsYukihiko Kinoshita0Hatsuhiko Maeda1Department of Oral Pathology, School of Dentistry, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, JapanDepartment of Oral Pathology, School of Dentistry, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, JapanAutogenous bone grafting remains a gold standard for the reconstruction critical-sized bone defects in the craniomaxillofacial region. Nevertheless, this graft procedure has several disadvantages such as restricted availability, donor-site morbidity, and limitations in regard to fully restoring the complicated three-dimensional structures in the craniomaxillofacial bone. The ultimate goal of craniomaxillofacial bone reconstruction is the regeneration of the physiological bone that simultaneously fulfills both morphological and functional restorations. Developments of tissue engineering in the last two decades have brought such a goal closer to reality. In bone tissue engineering, the scaffolds are fundamental, elemental and mesenchymal stem cells/osteoprogenitor cells and bioactive factors. A variety of scaffolds have been developed and used as spacemakers, biodegradable bone substitutes for transplanting to the new bone, matrices of drug delivery system, or supporting structures enhancing adhesion, proliferation, and matrix production of seeded cells according to the circumstances of the bone defects. However, scaffolds to be clinically completely satisfied have not been developed yet. Development of more functional scaffolds is required to be applied widely to cranio-maxillofacial bone defects. This paper reviews recent trends of scaffolds for crania-maxillofacial bone tissue engineering, including our studies.http://dx.doi.org/10.1155/2013/863157 |
| spellingShingle | Yukihiko Kinoshita Hatsuhiko Maeda Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications The Scientific World Journal |
| title | Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications |
| title_full | Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications |
| title_fullStr | Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications |
| title_full_unstemmed | Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications |
| title_short | Recent Developments of Functional Scaffolds for Craniomaxillofacial Bone Tissue Engineering Applications |
| title_sort | recent developments of functional scaffolds for craniomaxillofacial bone tissue engineering applications |
| url | http://dx.doi.org/10.1155/2013/863157 |
| work_keys_str_mv | AT yukihikokinoshita recentdevelopmentsoffunctionalscaffoldsforcraniomaxillofacialbonetissueengineeringapplications AT hatsuhikomaeda recentdevelopmentsoffunctionalscaffoldsforcraniomaxillofacialbonetissueengineeringapplications |