Regulating the PI3K and AMPK pathway: the secret of 1-deoxynojirimycin's success in alleviating chronic diseases
Abstracts: The chronic diseases (e.g. diabetes mellitus, obesity, and cardiovascular diseases) have become a global public health issue with its increasing morbidity and mortality. However, the effects of drug treatments are limited unless the diet or living habit are monitored and controlled. The t...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2025-11-01
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| Series: | Journal of Future Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772566924000909 |
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| author | Chengwei Yu Qirui Hu |
| author_facet | Chengwei Yu Qirui Hu |
| author_sort | Chengwei Yu |
| collection | DOAJ |
| description | Abstracts: The chronic diseases (e.g. diabetes mellitus, obesity, and cardiovascular diseases) have become a global public health issue with its increasing morbidity and mortality. However, the effects of drug treatments are limited unless the diet or living habit are monitored and controlled. The traditional Chinese medicine has advantages in treatment of chronic diseases because it can be utilized as both drug intervention and diet intervention. Mulberry leaf is a type of traditional Chinese medicine which possesses hpyerglycemic, anti-obesity, anti-inflammatory and anti-oxidative activities. Therefore, mulberry leaves are widely used to treat chronic diseases. The 1-deoxynojirimycin (DNJ) is the unique alkaloid and the primary component for hypoglycemic effects in the mulberry leaves. Meanwhile, DNJ has also been proved to exert anti-obesity, anti-cardiovascular diseases and anti-cancer effects. However, the underlying mechanisms are unclear yet, which hinders the applications of DNJ in clinic and food industry. Therefore, here we summarized the understanding of the molecular mechanisms underlying the effects of DNJ on the chronic diseases, proposed the key molecular mediators (phosphatidylinositol 3-kinase (PI3K) and adenosine 5′-monophosphate-activated protein kinase (AMPK)) and discussed the future directions to promote the application of DNJ. |
| format | Article |
| id | doaj-art-f0c93841008342f7805ca9a39eaa60df |
| institution | Kabale University |
| issn | 2772-5669 |
| language | English |
| publishDate | 2025-11-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Journal of Future Foods |
| spelling | doaj-art-f0c93841008342f7805ca9a39eaa60df2025-01-30T05:15:13ZengKeAi Communications Co. Ltd.Journal of Future Foods2772-56692025-11-0156551560Regulating the PI3K and AMPK pathway: the secret of 1-deoxynojirimycin's success in alleviating chronic diseasesChengwei Yu0Qirui Hu1School of Health, Jiangxi Normal University, Nanchang 330022, China; National Research and Development Center of Freshwater Fish Processing, College of Life Sciences, Jiangxi Normal University, Nanchang 330022, ChinaState Key Laboratory of Food Science and Resource, Nanchang University, Nanchang 330047, China; Corresponding author at: State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang 330047, China.Abstracts: The chronic diseases (e.g. diabetes mellitus, obesity, and cardiovascular diseases) have become a global public health issue with its increasing morbidity and mortality. However, the effects of drug treatments are limited unless the diet or living habit are monitored and controlled. The traditional Chinese medicine has advantages in treatment of chronic diseases because it can be utilized as both drug intervention and diet intervention. Mulberry leaf is a type of traditional Chinese medicine which possesses hpyerglycemic, anti-obesity, anti-inflammatory and anti-oxidative activities. Therefore, mulberry leaves are widely used to treat chronic diseases. The 1-deoxynojirimycin (DNJ) is the unique alkaloid and the primary component for hypoglycemic effects in the mulberry leaves. Meanwhile, DNJ has also been proved to exert anti-obesity, anti-cardiovascular diseases and anti-cancer effects. However, the underlying mechanisms are unclear yet, which hinders the applications of DNJ in clinic and food industry. Therefore, here we summarized the understanding of the molecular mechanisms underlying the effects of DNJ on the chronic diseases, proposed the key molecular mediators (phosphatidylinositol 3-kinase (PI3K) and adenosine 5′-monophosphate-activated protein kinase (AMPK)) and discussed the future directions to promote the application of DNJ.http://www.sciencedirect.com/science/article/pii/S27725669240009091-DeoxynojirimycinMulberry leavesDiabetes mellitusObesityCardiovascular disease |
| spellingShingle | Chengwei Yu Qirui Hu Regulating the PI3K and AMPK pathway: the secret of 1-deoxynojirimycin's success in alleviating chronic diseases Journal of Future Foods 1-Deoxynojirimycin Mulberry leaves Diabetes mellitus Obesity Cardiovascular disease |
| title | Regulating the PI3K and AMPK pathway: the secret of 1-deoxynojirimycin's success in alleviating chronic diseases |
| title_full | Regulating the PI3K and AMPK pathway: the secret of 1-deoxynojirimycin's success in alleviating chronic diseases |
| title_fullStr | Regulating the PI3K and AMPK pathway: the secret of 1-deoxynojirimycin's success in alleviating chronic diseases |
| title_full_unstemmed | Regulating the PI3K and AMPK pathway: the secret of 1-deoxynojirimycin's success in alleviating chronic diseases |
| title_short | Regulating the PI3K and AMPK pathway: the secret of 1-deoxynojirimycin's success in alleviating chronic diseases |
| title_sort | regulating the pi3k and ampk pathway the secret of 1 deoxynojirimycin s success in alleviating chronic diseases |
| topic | 1-Deoxynojirimycin Mulberry leaves Diabetes mellitus Obesity Cardiovascular disease |
| url | http://www.sciencedirect.com/science/article/pii/S2772566924000909 |
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