lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke
Abstract Cardiac myxoma (CM) is an important aetiology of stroke in young adults, and its diagnosis is difficult in patients having stroke because of the lack of diagnostic biomarkers. Tumour-derived exosomes play a crucial role in tumour growth, metastasis, immune regulation, and monitor disease de...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | Scientific Data |
| Online Access: | https://doi.org/10.1038/s41597-025-04410-4 |
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| author | Lin Ma Yu-Hua Liu Chun Liu Shu-Qi Wang Jun Ma Xiao-Qing Li Min Ren Ting-Ting Yang Guang-Zhi Liu |
| author_facet | Lin Ma Yu-Hua Liu Chun Liu Shu-Qi Wang Jun Ma Xiao-Qing Li Min Ren Ting-Ting Yang Guang-Zhi Liu |
| author_sort | Lin Ma |
| collection | DOAJ |
| description | Abstract Cardiac myxoma (CM) is an important aetiology of stroke in young adults, and its diagnosis is difficult in patients having stroke because of the lack of diagnostic biomarkers. Tumour-derived exosomes play a crucial role in tumour growth, metastasis, immune regulation, and monitor disease development. Hence,we established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM). Moreover, 5,533 lncRNAs, 1,331 known miRNAs, and 412 new miRNAs were identified. Finally, gene expression profiles and differentially expressed genes were analysed in 20 samples. In the plasma samples, 74 miRNAs, 12 lncRNAs, and 693 mRNAs were identified, while tumour-derived tissue samples contained 61 miRNAs, 67 lncRNAs, and 433 mRNAs. This dataset provides a significant resource for relevant researchers to explore the potential dysregulated lncRNAs, miRNAs, and mRNAs of plasma and tumour-derived exosomes in CM-IS. |
| format | Article |
| id | doaj-art-f0c87a845452424b88364a1e22707c18 |
| institution | Kabale University |
| issn | 2052-4463 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Data |
| spelling | doaj-art-f0c87a845452424b88364a1e22707c182025-01-19T12:09:57ZengNature PortfolioScientific Data2052-44632025-01-0112111210.1038/s41597-025-04410-4lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic strokeLin Ma0Yu-Hua Liu1Chun Liu2Shu-Qi Wang3Jun Ma4Xiao-Qing Li5Min Ren6Ting-Ting Yang7Guang-Zhi Liu8Department of Neurology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiosurgery, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Anzhen Hospital, Capital Medical UniversityNational Engineering Research Center for Biomaterials, Sichuan UniversityDepartment of Anesthesiology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Neurology, Shanghai Bluecross Brain Hospital, ShanghaiDepartment of Neurology, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Neurology, Beijing Anzhen Hospital, Capital Medical UniversityAbstract Cardiac myxoma (CM) is an important aetiology of stroke in young adults, and its diagnosis is difficult in patients having stroke because of the lack of diagnostic biomarkers. Tumour-derived exosomes play a crucial role in tumour growth, metastasis, immune regulation, and monitor disease development. Hence,we established an RNA-sequencing dataset for long non-coding RNA (lncRNA), microRNA (miRNA), and messenger RNA (mRNA) in the plasma and tumour-derived exosomes from four patients with cardiac myxoma-related ischaemic stroke (CM-IS) and six patients with cardiac myxoma without ischaemic stroke (non-IS CM). Moreover, 5,533 lncRNAs, 1,331 known miRNAs, and 412 new miRNAs were identified. Finally, gene expression profiles and differentially expressed genes were analysed in 20 samples. In the plasma samples, 74 miRNAs, 12 lncRNAs, and 693 mRNAs were identified, while tumour-derived tissue samples contained 61 miRNAs, 67 lncRNAs, and 433 mRNAs. This dataset provides a significant resource for relevant researchers to explore the potential dysregulated lncRNAs, miRNAs, and mRNAs of plasma and tumour-derived exosomes in CM-IS.https://doi.org/10.1038/s41597-025-04410-4 |
| spellingShingle | Lin Ma Yu-Hua Liu Chun Liu Shu-Qi Wang Jun Ma Xiao-Qing Li Min Ren Ting-Ting Yang Guang-Zhi Liu lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke Scientific Data |
| title | lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke |
| title_full | lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke |
| title_fullStr | lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke |
| title_full_unstemmed | lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke |
| title_short | lncRNA, miRNA, and mRNA of plasma and tumor-derived exosomes of cardiac myxoma-related ischaemic stroke |
| title_sort | lncrna mirna and mrna of plasma and tumor derived exosomes of cardiac myxoma related ischaemic stroke |
| url | https://doi.org/10.1038/s41597-025-04410-4 |
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