The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease
Mitochondria are highly dynamic organelles that are important for many diverse cellular processes, such as energy metabolism, calcium buffering, and apoptosis. Mitochondrial biology and dysfunction have recently been linked to different types of cancers and neurodegenerative diseases, most notably...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2012/382175 |
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| _version_ | 1832549898723000320 |
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| author | Riya Shanbhag Guang Shi Jarungjit Rujiviphat G. Angus McQuibban |
| author_facet | Riya Shanbhag Guang Shi Jarungjit Rujiviphat G. Angus McQuibban |
| author_sort | Riya Shanbhag |
| collection | DOAJ |
| description | Mitochondria are highly dynamic organelles that are important for many diverse cellular processes, such as energy metabolism, calcium buffering, and apoptosis. Mitochondrial biology and dysfunction have recently been linked to different types of cancers and neurodegenerative diseases, most notably Parkinson’s disease. Thus, a better understanding of the quality control systems that maintain a healthy mitochondrial network can facilitate the development of effective treatments for these diseases. In this perspective, we will discuss recent advances on two mitochondrial quality control pathways: the UPS and mitophagy, highlight how new players may be contributing to regulate these pathways. We believe the proteases involved will be key and novel regulators of mitochondrial quality control, and this knowledge will provide insights into future studies aimed to combat neurodegenerative diseases. |
| format | Article |
| id | doaj-art-f0bf6ae84be1457ebf175b964fa7018d |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-f0bf6ae84be1457ebf175b964fa7018d2025-02-03T06:08:21ZengWileyParkinson's Disease2090-80832042-00802012-01-01201210.1155/2012/382175382175The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s DiseaseRiya Shanbhag0Guang Shi1Jarungjit Rujiviphat2G. Angus McQuibban3Biochemistry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, CanadaBiochemistry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, CanadaBiochemistry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, CanadaBiochemistry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, CanadaMitochondria are highly dynamic organelles that are important for many diverse cellular processes, such as energy metabolism, calcium buffering, and apoptosis. Mitochondrial biology and dysfunction have recently been linked to different types of cancers and neurodegenerative diseases, most notably Parkinson’s disease. Thus, a better understanding of the quality control systems that maintain a healthy mitochondrial network can facilitate the development of effective treatments for these diseases. In this perspective, we will discuss recent advances on two mitochondrial quality control pathways: the UPS and mitophagy, highlight how new players may be contributing to regulate these pathways. We believe the proteases involved will be key and novel regulators of mitochondrial quality control, and this knowledge will provide insights into future studies aimed to combat neurodegenerative diseases.http://dx.doi.org/10.1155/2012/382175 |
| spellingShingle | Riya Shanbhag Guang Shi Jarungjit Rujiviphat G. Angus McQuibban The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease Parkinson's Disease |
| title | The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease |
| title_full | The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease |
| title_fullStr | The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease |
| title_full_unstemmed | The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease |
| title_short | The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease |
| title_sort | emerging role of proteolysis in mitochondrial quality control and the etiology of parkinson s disease |
| url | http://dx.doi.org/10.1155/2012/382175 |
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