Super-resolution microscopy as a drug discovery tool
At the turn of the century a fundamental resolution barrier in fluorescence microscopy known as the diffraction limit was broken, giving rise to the field of super-resolution microscopy. Subsequent nanoscopic investigation with visible light revolutionised our understanding of how previously unknown...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | SLAS Discovery |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2472555225000024 |
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| _version_ | 1832542481468620800 |
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| author | Lauren Toms Lorna FitzPatrick Philip Auckland |
| author_facet | Lauren Toms Lorna FitzPatrick Philip Auckland |
| author_sort | Lauren Toms |
| collection | DOAJ |
| description | At the turn of the century a fundamental resolution barrier in fluorescence microscopy known as the diffraction limit was broken, giving rise to the field of super-resolution microscopy. Subsequent nanoscopic investigation with visible light revolutionised our understanding of how previously unknown molecular features give rise to the emergent behaviour of cells. It transpires that the devil is in these fine molecular details, and essential nanoscale processes were found everywhere researchers chose to look. Now, after nearly two decades, super-resolution microscopy has begun to address previously unmet challenges in the study of human disease and is poised to become a pivotal tool in drug discovery. |
| format | Article |
| id | doaj-art-f0bdf8853c654aa68ea52f5d78880e17 |
| institution | Kabale University |
| issn | 2472-5552 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | SLAS Discovery |
| spelling | doaj-art-f0bdf8853c654aa68ea52f5d78880e172025-02-04T04:10:31ZengElsevierSLAS Discovery2472-55522025-03-0131100209Super-resolution microscopy as a drug discovery toolLauren Toms0Lorna FitzPatrick1Philip Auckland2Correspondence.; Medicines Discovery Catapult, Block 35, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4ZF, United KingdomMedicines Discovery Catapult, Block 35, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4ZF, United KingdomCorrespondence.; Medicines Discovery Catapult, Block 35, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4ZF, United KingdomAt the turn of the century a fundamental resolution barrier in fluorescence microscopy known as the diffraction limit was broken, giving rise to the field of super-resolution microscopy. Subsequent nanoscopic investigation with visible light revolutionised our understanding of how previously unknown molecular features give rise to the emergent behaviour of cells. It transpires that the devil is in these fine molecular details, and essential nanoscale processes were found everywhere researchers chose to look. Now, after nearly two decades, super-resolution microscopy has begun to address previously unmet challenges in the study of human disease and is poised to become a pivotal tool in drug discovery.http://www.sciencedirect.com/science/article/pii/S2472555225000024 |
| spellingShingle | Lauren Toms Lorna FitzPatrick Philip Auckland Super-resolution microscopy as a drug discovery tool SLAS Discovery |
| title | Super-resolution microscopy as a drug discovery tool |
| title_full | Super-resolution microscopy as a drug discovery tool |
| title_fullStr | Super-resolution microscopy as a drug discovery tool |
| title_full_unstemmed | Super-resolution microscopy as a drug discovery tool |
| title_short | Super-resolution microscopy as a drug discovery tool |
| title_sort | super resolution microscopy as a drug discovery tool |
| url | http://www.sciencedirect.com/science/article/pii/S2472555225000024 |
| work_keys_str_mv | AT laurentoms superresolutionmicroscopyasadrugdiscoverytool AT lornafitzpatrick superresolutionmicroscopyasadrugdiscoverytool AT philipauckland superresolutionmicroscopyasadrugdiscoverytool |