The Expression of Bcl-2 and BID in Gastric Cancer Cells
Background. Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence of Helicobacter pylor...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2014/953203 |
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| _version_ | 1832555893364883456 |
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| author | Mariusz Gryko Anna Pryczynicz Konrad Zareba Bogusław Kędra Andrzej Kemona Katarzyna Guzińska-Ustymowicz |
| author_facet | Mariusz Gryko Anna Pryczynicz Konrad Zareba Bogusław Kędra Andrzej Kemona Katarzyna Guzińska-Ustymowicz |
| author_sort | Mariusz Gryko |
| collection | DOAJ |
| description | Background. Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence of Helicobacter pylori infection, and patients’ survival. Materials and Methods. The study involved 88 patients operated on for gastric cancer. The expressions of Bcl-2 and BID were determined immunohistochemically. Results. Positive Bcl-2 expression was found in 55.7% and, BID in 53.6% of patients. The Bcl-2 expression correlated with stage pT3 and T4 gastric cancer P<0.05, with the intestinal type according to Lauren P<0.001, ulcerated type according to Bormann’s classification P<0.01, and with local lymph node metastases P<0.05. Conclusion. The Bcl-2 protein plays a key role in the process of gastric cancer formation and is associated with the growth of definite types of gastric cancer. |
| format | Article |
| id | doaj-art-f0bc27aa99424ba4ae24fc0b8d6bc73b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-f0bc27aa99424ba4ae24fc0b8d6bc73b2025-02-03T05:47:03ZengWileyJournal of Immunology Research2314-88612314-71562014-01-01201410.1155/2014/953203953203The Expression of Bcl-2 and BID in Gastric Cancer CellsMariusz Gryko0Anna Pryczynicz1Konrad Zareba2Bogusław Kędra3Andrzej Kemona4Katarzyna Guzińska-Ustymowicz5Second Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, PolandDepartment of General Pathomorphology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, PolandSecond Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, PolandSecond Department of General and Gastroenterological Surgery, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, PolandDepartment of General Pathomorphology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, PolandDepartment of General Pathomorphology, Medical University of Bialystok, M. Sklodowskiej-Curie 24a Street, 15-276 Bialystok, PolandBackground. Bcl-2 and BID play a major role in the process of apoptosis and their dysfunction underlies carcinogenesis. The study objective was to assess the expression of Bcl-2 and BID in gastric cancer cells in correlation with chosen clinicopathological parameters, presence of Helicobacter pylori infection, and patients’ survival. Materials and Methods. The study involved 88 patients operated on for gastric cancer. The expressions of Bcl-2 and BID were determined immunohistochemically. Results. Positive Bcl-2 expression was found in 55.7% and, BID in 53.6% of patients. The Bcl-2 expression correlated with stage pT3 and T4 gastric cancer P<0.05, with the intestinal type according to Lauren P<0.001, ulcerated type according to Bormann’s classification P<0.01, and with local lymph node metastases P<0.05. Conclusion. The Bcl-2 protein plays a key role in the process of gastric cancer formation and is associated with the growth of definite types of gastric cancer.http://dx.doi.org/10.1155/2014/953203 |
| spellingShingle | Mariusz Gryko Anna Pryczynicz Konrad Zareba Bogusław Kędra Andrzej Kemona Katarzyna Guzińska-Ustymowicz The Expression of Bcl-2 and BID in Gastric Cancer Cells Journal of Immunology Research |
| title | The Expression of Bcl-2 and BID in Gastric Cancer Cells |
| title_full | The Expression of Bcl-2 and BID in Gastric Cancer Cells |
| title_fullStr | The Expression of Bcl-2 and BID in Gastric Cancer Cells |
| title_full_unstemmed | The Expression of Bcl-2 and BID in Gastric Cancer Cells |
| title_short | The Expression of Bcl-2 and BID in Gastric Cancer Cells |
| title_sort | expression of bcl 2 and bid in gastric cancer cells |
| url | http://dx.doi.org/10.1155/2014/953203 |
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