Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals.

Blood-based epigenome-wide analyses of 19 common disease states: A longitudinal, population-based linked cohort study of 18,413 Scottish individuals.

<h4>Background</h4>DNA methylation is a dynamic epigenetic mechanism that occurs at cytosine-phosphate-guanine dinucleotide (CpG) sites. Epigenome-wide association studies (EWAS) investigate the strength of association between methylation at individual CpG sites and health outcomes. Alth...

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Main Authors: Robert F Hillary, Daniel L McCartney, Hannah M Smith, Elena Bernabeu, Danni A Gadd, Aleksandra D Chybowska, Yipeng Cheng, Lee Murphy, Nicola Wrobel, Archie Campbell, Rosie M Walker, Caroline Hayward, Kathryn L Evans, Andrew M McIntosh, Riccardo E Marioni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-07-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1004247&type=printable
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