Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: a case report
BackgroundAnorectal malignant melanoma is a rare subtype of melanoma with a poor prognosis. Despite this, some patients decline Miles’ operation due to the sigmoid colostomies that follow abdominoperineal resections in cases of anorectal malignant melanoma.Case reportWe report the case of an 80-year...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1465645/full |
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| author | Xuejun Jiang Zujin Ji Peng Li Fangjun Yuan Xinyi Lei Yong Yang |
| author_facet | Xuejun Jiang Zujin Ji Peng Li Fangjun Yuan Xinyi Lei Yong Yang |
| author_sort | Xuejun Jiang |
| collection | DOAJ |
| description | BackgroundAnorectal malignant melanoma is a rare subtype of melanoma with a poor prognosis. Despite this, some patients decline Miles’ operation due to the sigmoid colostomies that follow abdominoperineal resections in cases of anorectal malignant melanoma.Case reportWe report the case of an 80-year-old woman diagnosed with anorectal malignant melanoma who underwent cryosurgery accompanied by adjuvant PD-1 therapy to maintain anal sphincter function. The results indicated that we successfully achieved the goal of sphincter preservation and therapeutic efficacy. The patient derived significant benefits from the cryoablation treatment.ConclusionsUltrasound-guided trans-anal cryoablation, when combined with adjuvant PD-1 therapy, offers a novel treatment approach for patients with anorectal malignant melanoma. Our results have confirmed the advantages of this treatment regimen, particularly for those desiring to retain anal sphincter function. Further studies are required to substantiate the efficacy of ultrasound-guided trans-anal cryoablation with adjuvant Toripalimab and to elucidate its underlying mechanisms. |
| format | Article |
| id | doaj-art-f0a7676c5dec4cdebba1b39fc0f6c0c9 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-f0a7676c5dec4cdebba1b39fc0f6c0c92025-01-24T05:21:16ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.14656451465645Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: a case reportXuejun Jiang0Zujin Ji1Peng Li2Fangjun Yuan3Xinyi Lei4Yong Yang5Department of Colorectal and Anal Surgery, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Colorectal and Anal Surgery, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Medical Ultrasonics, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of General Surgery, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Colorectal and Anal Surgery, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaDepartment of Colorectal and Anal Surgery, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, Hubei, ChinaBackgroundAnorectal malignant melanoma is a rare subtype of melanoma with a poor prognosis. Despite this, some patients decline Miles’ operation due to the sigmoid colostomies that follow abdominoperineal resections in cases of anorectal malignant melanoma.Case reportWe report the case of an 80-year-old woman diagnosed with anorectal malignant melanoma who underwent cryosurgery accompanied by adjuvant PD-1 therapy to maintain anal sphincter function. The results indicated that we successfully achieved the goal of sphincter preservation and therapeutic efficacy. The patient derived significant benefits from the cryoablation treatment.ConclusionsUltrasound-guided trans-anal cryoablation, when combined with adjuvant PD-1 therapy, offers a novel treatment approach for patients with anorectal malignant melanoma. Our results have confirmed the advantages of this treatment regimen, particularly for those desiring to retain anal sphincter function. Further studies are required to substantiate the efficacy of ultrasound-guided trans-anal cryoablation with adjuvant Toripalimab and to elucidate its underlying mechanisms.https://www.frontiersin.org/articles/10.3389/fonc.2025.1465645/fullanorectal malignant melanomacryosurgerysphincter preservationcase reportToripalimabPD-1 |
| spellingShingle | Xuejun Jiang Zujin Ji Peng Li Fangjun Yuan Xinyi Lei Yong Yang Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: a case report Frontiers in Oncology anorectal malignant melanoma cryosurgery sphincter preservation case report Toripalimab PD-1 |
| title | Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: a case report |
| title_full | Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: a case report |
| title_fullStr | Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: a case report |
| title_full_unstemmed | Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: a case report |
| title_short | Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: a case report |
| title_sort | long term survival following cryoablation with adjuvant toripalimab for anorectal malignant melanoma a case report |
| topic | anorectal malignant melanoma cryosurgery sphincter preservation case report Toripalimab PD-1 |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1465645/full |
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