CEREBRAL HEMODYNAMICS IN PATIENTS WITH HYPERTENSION COMBINED WITH ERYTHROCYTOSIS
Introduction. Cerebrovascular diseases, which include acute forms (such as stroke and transient ischemic attack) and chronic forms (such as discirculatory encephalopathy), are among the most significant medical and social problems both in our country and worldwide due to their high prevalence and se...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
State Institution of Science «Research and Practical Center of Preventive and Clinical Medicine» State Administrative Department
2025-04-01
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| Series: | Клінічна та профілактична медицина |
| Subjects: | |
| Online Access: | https://cp-medical.com/index.php/journal/article/view/576 |
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| Summary: | Introduction. Cerebrovascular diseases, which include acute forms (such as stroke and transient ischemic attack) and chronic forms (such as discirculatory encephalopathy), are among the most significant medical and social problems both in our country and worldwide due to their high prevalence and severe consequences. One of the causes of chronic brain ischemia can be the disturbance of blood rheological properties, specifically its thickening. Erythrocytosis is one such factor.
Aim. To determine the characteristics of the course of discirculatory encephalopathy (DE) in patients with erythrocytosis combined with hypertension.
Materials and methods. This study employed a clinical-neurological examination alongside neuropsychological, instrumental, laboratory, and statistical methods. The analysis included data from clinical studies of 90 patients divided into 3 groups. For statistical analysis comparing the three groups, analysis of variance (for normally distributed data) or the Kruskal-Wallis test (for non-normally distributed data) was used for quantitative variables. The chi-square test was used for qualitative variables. Post-hoc comparisons for quantitative variables were conducted using the Scheffé criterion or the Dunn criterion, as appropriate.
Conclusions. The course of discirculatory encephalopathy in the context of hypertension combined with erythrocytosis exhibits distinct characteristics. In the study of cerebral blood flow, a significant decrease in flow velocities was observed in the vertebrobasilar and carotid basins among patients who had experienced a stroke compared to those with erythrocytosis combined with hypertension. Conversely, cerebral blood flow velocities in the control group differed significantly from both patient groups and corresponded to normal values. Therefore, we assert that the combination of erythrocytosis and hypertension is a significant factor in chronic brain ischemia, leading to cognitive and psycho-emotional disorders. |
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| ISSN: | 2616-4868 |