Clinical profile and risk factors for respiratory failure in children with Mycoplasma pneumoniae infection
Mycoplasma pneumoniae (MP) is a common cause of community-acquired pneumonia (CAP) in children and can lead to severe complications, including respiratory failure. A retrospective analysis of 2,084 children diagnosed with CAP and treated in our hospital from January 2022 to January 2023 was conduct...
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2025-01-01
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| Series: | Biomolecules & Biomedicine |
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| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/11641 |
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| author | Yanfei Wang Limin Huang Junjie Qian Kelei Deng Zihao Yang Zhenjie Chen Wei Li Linhua Tan |
| author_facet | Yanfei Wang Limin Huang Junjie Qian Kelei Deng Zihao Yang Zhenjie Chen Wei Li Linhua Tan |
| author_sort | Yanfei Wang |
| collection | DOAJ |
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Mycoplasma pneumoniae (MP) is a common cause of community-acquired pneumonia (CAP) in children and can lead to severe complications, including respiratory failure. A retrospective analysis of 2,084 children diagnosed with CAP and treated in our hospital from January 2022 to January 2023 was conducted. A comprehensive dataset of patient demographics, clinical symptoms, and laboratory findings was initially assembled. Subsequent statistical analyses were carried out to elucidate the clinical characteristics of Mycoplasma pneumoniae pneumonia (MPP) in children. Additionally, the study identified high-risk factors for respiratory failure in the context of MPP. Among the hospitalized MPP cases, 15.8% progressed to respiratory failure. Statistical analysis identified D-dimer level as a significant risk factor for respiratory failure in children with MPP. A predictive model was developed using D-dimer levels, yielding an area under the curve (AUC) of 0.818 with a cutoff value of 1.015 mg/L. The model demonstrated a sensitivity of 62.4% and a specificity of 91.3%, proving effective in predicting respiratory failure caused by MPP. Respiratory failure remains a critical complication in children with MPP, and D-dimer levels serve as a key predictive risk factor. Vigilant monitoring of coagulation function, particularly D-dimer levels, is essential for the early identification of patients at risk of developing respiratory failure in MPP cases.
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| format | Article |
| id | doaj-art-f07caa29509949338a9709e519896340 |
| institution | Kabale University |
| issn | 2831-0896 2831-090X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj-art-f07caa29509949338a9709e5198963402025-01-22T16:40:57ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2025-01-0110.17305/bb.2024.11641Clinical profile and risk factors for respiratory failure in children with Mycoplasma pneumoniae infectionYanfei Wang0https://orcid.org/0009-0005-9501-9138Limin Huang1Junjie Qian2Kelei Deng3Zihao Yang4Zhenjie Chen5Wei Li6Linhua Tan7Department of Surgical ICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Nephrology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Surgical ICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Surgical ICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Pediatric ICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Pediatric ICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, ChinaDepartment of Surgical ICU, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China Mycoplasma pneumoniae (MP) is a common cause of community-acquired pneumonia (CAP) in children and can lead to severe complications, including respiratory failure. A retrospective analysis of 2,084 children diagnosed with CAP and treated in our hospital from January 2022 to January 2023 was conducted. A comprehensive dataset of patient demographics, clinical symptoms, and laboratory findings was initially assembled. Subsequent statistical analyses were carried out to elucidate the clinical characteristics of Mycoplasma pneumoniae pneumonia (MPP) in children. Additionally, the study identified high-risk factors for respiratory failure in the context of MPP. Among the hospitalized MPP cases, 15.8% progressed to respiratory failure. Statistical analysis identified D-dimer level as a significant risk factor for respiratory failure in children with MPP. A predictive model was developed using D-dimer levels, yielding an area under the curve (AUC) of 0.818 with a cutoff value of 1.015 mg/L. The model demonstrated a sensitivity of 62.4% and a specificity of 91.3%, proving effective in predicting respiratory failure caused by MPP. Respiratory failure remains a critical complication in children with MPP, and D-dimer levels serve as a key predictive risk factor. Vigilant monitoring of coagulation function, particularly D-dimer levels, is essential for the early identification of patients at risk of developing respiratory failure in MPP cases. https://www.bjbms.org/ojs/index.php/bjbms/article/view/11641Mycoplasma pneumoniaeMPrespiratory failureclinical disease prediction model |
| spellingShingle | Yanfei Wang Limin Huang Junjie Qian Kelei Deng Zihao Yang Zhenjie Chen Wei Li Linhua Tan Clinical profile and risk factors for respiratory failure in children with Mycoplasma pneumoniae infection Biomolecules & Biomedicine Mycoplasma pneumoniae MP respiratory failure clinical disease prediction model |
| title | Clinical profile and risk factors for respiratory failure in children with Mycoplasma pneumoniae infection |
| title_full | Clinical profile and risk factors for respiratory failure in children with Mycoplasma pneumoniae infection |
| title_fullStr | Clinical profile and risk factors for respiratory failure in children with Mycoplasma pneumoniae infection |
| title_full_unstemmed | Clinical profile and risk factors for respiratory failure in children with Mycoplasma pneumoniae infection |
| title_short | Clinical profile and risk factors for respiratory failure in children with Mycoplasma pneumoniae infection |
| title_sort | clinical profile and risk factors for respiratory failure in children with mycoplasma pneumoniae infection |
| topic | Mycoplasma pneumoniae MP respiratory failure clinical disease prediction model |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/11641 |
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