Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study
Limited data are available about mitotane-nduced hyperlipidemia. We retrospectively analyzed lipid data in 38 patients with adrenocortical carcinoma (ACC) who received mitotane therapy with emphasis on HDL cholesterol (HDL-c) and clinical predictors of lipid changes. At baseline, the mean levels of...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/624962 |
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| author | Hassan Shawa Ferhat Deniz Hadil Bazerbashi Mike Hernandez Rena Vassilopoulou-Sellin Camilo Jimenez Mouhammed Amir Habra |
| author_facet | Hassan Shawa Ferhat Deniz Hadil Bazerbashi Mike Hernandez Rena Vassilopoulou-Sellin Camilo Jimenez Mouhammed Amir Habra |
| author_sort | Hassan Shawa |
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| description | Limited data are available about mitotane-nduced hyperlipidemia. We retrospectively analyzed lipid data in 38 patients with adrenocortical carcinoma (ACC) who received mitotane therapy with emphasis on HDL cholesterol (HDL-c) and clinical predictors of lipid changes. At baseline, the mean levels of HDL-c, LDL-c, and triglycerides were 53.3 mg/dL, 114.4 mg/dL, and 149 mg/dL, respectively. HDL-c, LDL-c, and triglyceride concentrations significantly increased with mitotane therapy to a mean HDL peak (HDL-P) of 86.3 mg/dL (P<0.001), a mean LDL peak of 160.1 mg/dL (P<0.001), and a mean triglyceride peak (Tg-P) of 216.7 mg/dL (P=0.042). HDL-P positively correlated with mitotane concentration (r=0.52,P<0.001), while LDL-P levels and Tg-P did not. Gender, body mass index, cortisol overproduction, baseline levels of HDL-c, and triglyceride did not predict change in HDL-c. Similar changes were noticed in subgroup analysis after excluding patients who were using lipid-lowering agents. In conclusion, in ACC patients, mitotane caused significant increases in HDL-c that may counteract the deleterious atherosclerotic effects of LDL-c and Tg rise. Understanding the mechanism of HDL change may lead to the discovery of novel HDL-c-elevating drugs. |
| format | Article |
| id | doaj-art-f06f2d947d054f61b0f1c95edb25060c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f06f2d947d054f61b0f1c95edb25060c2025-02-03T01:20:45ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/624962624962Mitotane-Induced Hyperlipidemia: A Retrospective Cohort StudyHassan Shawa0Ferhat Deniz1Hadil Bazerbashi2Mike Hernandez3Rena Vassilopoulou-Sellin4Camilo Jimenez5Mouhammed Amir Habra6Department of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAThe University of Texas School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USADepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Endocrine Neoplasia and Hormonal Disorders, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USALimited data are available about mitotane-nduced hyperlipidemia. We retrospectively analyzed lipid data in 38 patients with adrenocortical carcinoma (ACC) who received mitotane therapy with emphasis on HDL cholesterol (HDL-c) and clinical predictors of lipid changes. At baseline, the mean levels of HDL-c, LDL-c, and triglycerides were 53.3 mg/dL, 114.4 mg/dL, and 149 mg/dL, respectively. HDL-c, LDL-c, and triglyceride concentrations significantly increased with mitotane therapy to a mean HDL peak (HDL-P) of 86.3 mg/dL (P<0.001), a mean LDL peak of 160.1 mg/dL (P<0.001), and a mean triglyceride peak (Tg-P) of 216.7 mg/dL (P=0.042). HDL-P positively correlated with mitotane concentration (r=0.52,P<0.001), while LDL-P levels and Tg-P did not. Gender, body mass index, cortisol overproduction, baseline levels of HDL-c, and triglyceride did not predict change in HDL-c. Similar changes were noticed in subgroup analysis after excluding patients who were using lipid-lowering agents. In conclusion, in ACC patients, mitotane caused significant increases in HDL-c that may counteract the deleterious atherosclerotic effects of LDL-c and Tg rise. Understanding the mechanism of HDL change may lead to the discovery of novel HDL-c-elevating drugs.http://dx.doi.org/10.1155/2013/624962 |
| spellingShingle | Hassan Shawa Ferhat Deniz Hadil Bazerbashi Mike Hernandez Rena Vassilopoulou-Sellin Camilo Jimenez Mouhammed Amir Habra Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study International Journal of Endocrinology |
| title | Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study |
| title_full | Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study |
| title_fullStr | Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study |
| title_full_unstemmed | Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study |
| title_short | Mitotane-Induced Hyperlipidemia: A Retrospective Cohort Study |
| title_sort | mitotane induced hyperlipidemia a retrospective cohort study |
| url | http://dx.doi.org/10.1155/2013/624962 |
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