Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System
Mesenchymal stromal cells (MSCs), formerly known as mesenchymal stem cells, are nonhematopoietic multipotent cells and are emerging worldwide as the most clinically used and promising source for allogeneic cell therapy. MSCs, initially obtained from bone marrow, can be derived from several other tis...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/7219297 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556232838217728 |
|---|---|
| author | Bella S. Guerrouahen Heba Sidahmed Asma Al Sulaiti Moza Al Khulaifi Chiara Cugno |
| author_facet | Bella S. Guerrouahen Heba Sidahmed Asma Al Sulaiti Moza Al Khulaifi Chiara Cugno |
| author_sort | Bella S. Guerrouahen |
| collection | DOAJ |
| description | Mesenchymal stromal cells (MSCs), formerly known as mesenchymal stem cells, are nonhematopoietic multipotent cells and are emerging worldwide as the most clinically used and promising source for allogeneic cell therapy. MSCs, initially obtained from bone marrow, can be derived from several other tissues, such as adipose tissue, placenta, and umbilical cord. Diversity in tissue sourcing and manufacturing procedures has significant effects on MSC products. However, in 2006, a minimal set of standard criteria has been issued by the International Society of Cellular Therapy for defining derived MSCs. These include adherence to plastic in conventional culture conditions, particular phenotype, and multilineage differentiation capacity in vitro. Moreover, MSCs have trophic capabilities, a high in vitro self-renewal ability, and immunomodulatory characteristics. Thus, immunosuppressive treatment with MSCs has been proposed as a potential therapeutic alternative for conditions in which the immune system cells influence outcomes, such as inflammatory and autoimmune diseases. The precise mechanism by which MSCs affect functions of most immune effector cells is not completely understood but involves direct contact with immune cells, soluble mediators, and local microenvironmental factors. Recently, it has been shown that their homeostatic resting state requires activation, which can be achieved in vitro with various cytokines, including interferon-γ. In the present review, we focus on the suppressive effect that MSCs exert on the immune system and highlight the significance of in vitro preconditioning and its use in preclinical studies. We discuss the clinical aspects of using MSCs as an immunomodulatory treatment. Finally, we comment on the risk of interfering with the immune system in regard to cancer formation and development. |
| format | Article |
| id | doaj-art-f06d922e9e1b484d8619a6b9ab989b58 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f06d922e9e1b484d8619a6b9ab989b582025-02-03T05:46:06ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/72192977219297Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune SystemBella S. Guerrouahen0Heba Sidahmed1Asma Al Sulaiti2Moza Al Khulaifi3Chiara Cugno4Sidra Medicine, Member of Qatar Foundation, Doha, QatarSidra Medicine, Member of Qatar Foundation, Doha, QatarSidra Medicine, Member of Qatar Foundation, Doha, QatarSidra Medicine, Member of Qatar Foundation, Doha, QatarSidra Medicine, Member of Qatar Foundation, Doha, QatarMesenchymal stromal cells (MSCs), formerly known as mesenchymal stem cells, are nonhematopoietic multipotent cells and are emerging worldwide as the most clinically used and promising source for allogeneic cell therapy. MSCs, initially obtained from bone marrow, can be derived from several other tissues, such as adipose tissue, placenta, and umbilical cord. Diversity in tissue sourcing and manufacturing procedures has significant effects on MSC products. However, in 2006, a minimal set of standard criteria has been issued by the International Society of Cellular Therapy for defining derived MSCs. These include adherence to plastic in conventional culture conditions, particular phenotype, and multilineage differentiation capacity in vitro. Moreover, MSCs have trophic capabilities, a high in vitro self-renewal ability, and immunomodulatory characteristics. Thus, immunosuppressive treatment with MSCs has been proposed as a potential therapeutic alternative for conditions in which the immune system cells influence outcomes, such as inflammatory and autoimmune diseases. The precise mechanism by which MSCs affect functions of most immune effector cells is not completely understood but involves direct contact with immune cells, soluble mediators, and local microenvironmental factors. Recently, it has been shown that their homeostatic resting state requires activation, which can be achieved in vitro with various cytokines, including interferon-γ. In the present review, we focus on the suppressive effect that MSCs exert on the immune system and highlight the significance of in vitro preconditioning and its use in preclinical studies. We discuss the clinical aspects of using MSCs as an immunomodulatory treatment. Finally, we comment on the risk of interfering with the immune system in regard to cancer formation and development.http://dx.doi.org/10.1155/2019/7219297 |
| spellingShingle | Bella S. Guerrouahen Heba Sidahmed Asma Al Sulaiti Moza Al Khulaifi Chiara Cugno Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System Stem Cells International |
| title | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| title_full | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| title_fullStr | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| title_full_unstemmed | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| title_short | Enhancing Mesenchymal Stromal Cell Immunomodulation for Treating Conditions Influenced by the Immune System |
| title_sort | enhancing mesenchymal stromal cell immunomodulation for treating conditions influenced by the immune system |
| url | http://dx.doi.org/10.1155/2019/7219297 |
| work_keys_str_mv | AT bellasguerrouahen enhancingmesenchymalstromalcellimmunomodulationfortreatingconditionsinfluencedbytheimmunesystem AT hebasidahmed enhancingmesenchymalstromalcellimmunomodulationfortreatingconditionsinfluencedbytheimmunesystem AT asmaalsulaiti enhancingmesenchymalstromalcellimmunomodulationfortreatingconditionsinfluencedbytheimmunesystem AT mozaalkhulaifi enhancingmesenchymalstromalcellimmunomodulationfortreatingconditionsinfluencedbytheimmunesystem AT chiaracugno enhancingmesenchymalstromalcellimmunomodulationfortreatingconditionsinfluencedbytheimmunesystem |