Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood
While most circulating angiotensinogen (AGT) is synthesized in the liver, the kidneys also produce AGT. Recently, we reported that urinary AGT is mainly originated from AGT. Using newly developed human AGT ELISA, we measured urinary AGT levels in chronic glomerulonephritis (GN) patients and patients...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/206835 |
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| author | Maki Urushihara Shoji Kagami |
| author_facet | Maki Urushihara Shoji Kagami |
| author_sort | Maki Urushihara |
| collection | DOAJ |
| description | While most circulating angiotensinogen (AGT) is synthesized in the liver, the kidneys also produce AGT. Recently, we reported that urinary AGT is mainly originated from AGT. Using newly developed human AGT ELISA, we measured urinary AGT levels in chronic glomerulonephritis (GN) patients and patients with type 1 diabetes in childhood. Urinary AGT level was positively correlated with diastolic blood pressure, urinary albumin, urinary protein levels, and urinary occult blood in chronic GN patients. Furthermore, urinary AGT level was significantly increased in chronic GN patients not treated with renin-angiotensin system (RAS) blockers compared with control subjects. Importantly, patients treated with RAS blockers had a marked attenuation of this increase. Also, urinary AGT level was significantly higher in patients with diabetic nephropathy in the premicroalbuminuric phase than in control subjects. These results suggest that urinary AGT reflects intrarenal RAS status in chronic GN and may be an early marker of diabetic nephropathy. |
| format | Article |
| id | doaj-art-f06aab68da234a0b8e2bd15b02e48ac9 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-f06aab68da234a0b8e2bd15b02e48ac92025-02-03T05:44:47ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/206835206835Urinary Angiotensinogen as a Biomarker of Nephropathy in ChildhoodMaki Urushihara0Shoji Kagami1Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-cho 3-18-15, Tokushima 770-8503, JapanDepartment of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-cho 3-18-15, Tokushima 770-8503, JapanWhile most circulating angiotensinogen (AGT) is synthesized in the liver, the kidneys also produce AGT. Recently, we reported that urinary AGT is mainly originated from AGT. Using newly developed human AGT ELISA, we measured urinary AGT levels in chronic glomerulonephritis (GN) patients and patients with type 1 diabetes in childhood. Urinary AGT level was positively correlated with diastolic blood pressure, urinary albumin, urinary protein levels, and urinary occult blood in chronic GN patients. Furthermore, urinary AGT level was significantly increased in chronic GN patients not treated with renin-angiotensin system (RAS) blockers compared with control subjects. Importantly, patients treated with RAS blockers had a marked attenuation of this increase. Also, urinary AGT level was significantly higher in patients with diabetic nephropathy in the premicroalbuminuric phase than in control subjects. These results suggest that urinary AGT reflects intrarenal RAS status in chronic GN and may be an early marker of diabetic nephropathy.http://dx.doi.org/10.4061/2011/206835 |
| spellingShingle | Maki Urushihara Shoji Kagami Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood International Journal of Nephrology |
| title | Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood |
| title_full | Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood |
| title_fullStr | Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood |
| title_full_unstemmed | Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood |
| title_short | Urinary Angiotensinogen as a Biomarker of Nephropathy in Childhood |
| title_sort | urinary angiotensinogen as a biomarker of nephropathy in childhood |
| url | http://dx.doi.org/10.4061/2011/206835 |
| work_keys_str_mv | AT makiurushihara urinaryangiotensinogenasabiomarkerofnephropathyinchildhood AT shojikagami urinaryangiotensinogenasabiomarkerofnephropathyinchildhood |