Clinical Significance of the Peripheral Blood Neutrophil-to-Lymphocyte Ratio in Predicting Chemotherapy Outcomes for Small Cell Lung Cancer
Li Gao, Bin Liu Department of Respiratory and Critical Care Medicine, Fuyang People’s Hospital, Fuyang, 236000, People’s Republic of ChinaCorrespondence: Li Gao, Department of Respiratory and Critical Care Medicine, Fuyang People’s Hospital, No. 501, Sanqing Road, Qinghe Street, Yingzhou District, F...
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Dove Medical Press
2025-01-01
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| description | Li Gao, Bin Liu Department of Respiratory and Critical Care Medicine, Fuyang People’s Hospital, Fuyang, 236000, People’s Republic of ChinaCorrespondence: Li Gao, Department of Respiratory and Critical Care Medicine, Fuyang People’s Hospital, No. 501, Sanqing Road, Qinghe Street, Yingzhou District, Fuyang, 236000, People’s Republic of China, Tel +86 0558-3010308, Email gaoliheibeu@126.comObjective: This study aims to assess the clinical significance of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) in predicting chemotherapy outcomes for patients with small cell lung cancer (SCLC).Methods: A cohort of 44 patients diagnosed with SCLC between January 2021 to June 2022 at Fuyang People’s Hospital was selected for analysis. All patients in this group received a first-line platinum-based doublet chemotherapy regimen. In parallel, a control group consisting of 44 healthy individuals undergoing routine physical examinations at the same hospital was also selected. Fasting venous blood samples were collected in the morning within one week before the initiation of chemotherapy, and a complete blood cell count was performed to calculate the NLR.Results: The NLR in the plasma of patients with SCLC was significantly elevated compared to that of healthy individuals (P < 0.01). After two cycles of chemotherapy, there were no statistically significant differences in plasma NLR in SCLC patients compared to pre-chemotherapy levels (P > 0.05). However, in the subgroup of patients with a partial response (PR) to treatment, the NLR decreased to 2.625 (95% CI: 1.900, 3.625), down from a pre-chemotherapy level of 3.430 (2.688, 4.800) (Z = − 3.127, P = 0.002). Conversely, in patients whose disease progressed (PD) following chemotherapy, the NLR increased to 3.880 (95% CI: 2.953, 5.223) from a pre-chemotherapy level of 2.060 (1.915, 2.968) (Z = − 2.521, P = 0.012).Conclusion: The dynamic variations in the peripheral blood NLR before and after chemotherapy in patients with SCLC are strongly associated with the efficacy of first-line chemotherapy regimens. These changes in NLR levels may serve as a crucial indicator for predicting the effectiveness of first-line chemotherapy in patients with SCLC.Keywords: chemotherapy effectiveness, efficacy prediction, inflammatory response, neutrophil-to-lymphocyte ratio, small cell lung cancer |
| format | Article |
| id | doaj-art-f060f608b5684769a9384951c9248af9 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| series | Cancer Management and Research |
| spelling | doaj-art-f060f608b5684769a9384951c9248af92025-01-23T18:50:32ZengDove Medical PressCancer Management and Research1179-13222025-01-01Volume 1711311999496Clinical Significance of the Peripheral Blood Neutrophil-to-Lymphocyte Ratio in Predicting Chemotherapy Outcomes for Small Cell Lung CancerGao LLiu BLi Gao, Bin Liu Department of Respiratory and Critical Care Medicine, Fuyang People’s Hospital, Fuyang, 236000, People’s Republic of ChinaCorrespondence: Li Gao, Department of Respiratory and Critical Care Medicine, Fuyang People’s Hospital, No. 501, Sanqing Road, Qinghe Street, Yingzhou District, Fuyang, 236000, People’s Republic of China, Tel +86 0558-3010308, Email gaoliheibeu@126.comObjective: This study aims to assess the clinical significance of the peripheral blood neutrophil-to-lymphocyte ratio (NLR) in predicting chemotherapy outcomes for patients with small cell lung cancer (SCLC).Methods: A cohort of 44 patients diagnosed with SCLC between January 2021 to June 2022 at Fuyang People’s Hospital was selected for analysis. All patients in this group received a first-line platinum-based doublet chemotherapy regimen. In parallel, a control group consisting of 44 healthy individuals undergoing routine physical examinations at the same hospital was also selected. Fasting venous blood samples were collected in the morning within one week before the initiation of chemotherapy, and a complete blood cell count was performed to calculate the NLR.Results: The NLR in the plasma of patients with SCLC was significantly elevated compared to that of healthy individuals (P < 0.01). After two cycles of chemotherapy, there were no statistically significant differences in plasma NLR in SCLC patients compared to pre-chemotherapy levels (P > 0.05). However, in the subgroup of patients with a partial response (PR) to treatment, the NLR decreased to 2.625 (95% CI: 1.900, 3.625), down from a pre-chemotherapy level of 3.430 (2.688, 4.800) (Z = − 3.127, P = 0.002). Conversely, in patients whose disease progressed (PD) following chemotherapy, the NLR increased to 3.880 (95% CI: 2.953, 5.223) from a pre-chemotherapy level of 2.060 (1.915, 2.968) (Z = − 2.521, P = 0.012).Conclusion: The dynamic variations in the peripheral blood NLR before and after chemotherapy in patients with SCLC are strongly associated with the efficacy of first-line chemotherapy regimens. These changes in NLR levels may serve as a crucial indicator for predicting the effectiveness of first-line chemotherapy in patients with SCLC.Keywords: chemotherapy effectiveness, efficacy prediction, inflammatory response, neutrophil-to-lymphocyte ratio, small cell lung cancerhttps://www.dovepress.com/clinical-significance-of-the-peripheral-blood-neutrophil-to-lymphocyte-peer-reviewed-fulltext-article-CMARchemotherapy effectivenessefficacy predictioninflammatory responseneutrophil-to-lymphocyte ratiosmall cell lung cancer |
| spellingShingle | Gao L Liu B Clinical Significance of the Peripheral Blood Neutrophil-to-Lymphocyte Ratio in Predicting Chemotherapy Outcomes for Small Cell Lung Cancer Cancer Management and Research chemotherapy effectiveness efficacy prediction inflammatory response neutrophil-to-lymphocyte ratio small cell lung cancer |
| title | Clinical Significance of the Peripheral Blood Neutrophil-to-Lymphocyte Ratio in Predicting Chemotherapy Outcomes for Small Cell Lung Cancer |
| title_full | Clinical Significance of the Peripheral Blood Neutrophil-to-Lymphocyte Ratio in Predicting Chemotherapy Outcomes for Small Cell Lung Cancer |
| title_fullStr | Clinical Significance of the Peripheral Blood Neutrophil-to-Lymphocyte Ratio in Predicting Chemotherapy Outcomes for Small Cell Lung Cancer |
| title_full_unstemmed | Clinical Significance of the Peripheral Blood Neutrophil-to-Lymphocyte Ratio in Predicting Chemotherapy Outcomes for Small Cell Lung Cancer |
| title_short | Clinical Significance of the Peripheral Blood Neutrophil-to-Lymphocyte Ratio in Predicting Chemotherapy Outcomes for Small Cell Lung Cancer |
| title_sort | clinical significance of the peripheral blood neutrophil to lymphocyte ratio in predicting chemotherapy outcomes for small cell lung cancer |
| topic | chemotherapy effectiveness efficacy prediction inflammatory response neutrophil-to-lymphocyte ratio small cell lung cancer |
| url | https://www.dovepress.com/clinical-significance-of-the-peripheral-blood-neutrophil-to-lymphocyte-peer-reviewed-fulltext-article-CMAR |
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