Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer
Cardiovascular complications are a leading cause of therapy-related morbidity and mortality in long-term survivors of childhood malignancy. In fact, childhood cancer survivors are at a 15-fold risk of developing CHF compared to age-matched controls. There is a strong dose-dependent association betwe...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/713294 |
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| author | Saro H. Armenian Sarah K. Gelehrter Eric J. Chow |
| author_facet | Saro H. Armenian Sarah K. Gelehrter Eric J. Chow |
| author_sort | Saro H. Armenian |
| collection | DOAJ |
| description | Cardiovascular complications are a leading cause of therapy-related morbidity and mortality in long-term survivors of childhood malignancy. In fact, childhood cancer survivors are at a 15-fold risk of developing CHF compared to age-matched controls. There is a strong dose-dependent association between anthracycline exposure and risk of CHF, and the incidence increases with longer followup. Outcome following diagnosis of CHF is generally poor, with overall survival less than 50% at 5 years. The growing number of childhood cancer survivors makes it imperative that strategies be developed to prevent symptomatic heart disease in this vulnerable population. We present here an overview of the current state of knowledge regarding primary, secondary, and tertiary prevention strategies for childhood cancer survivors at high risk for CHF, drawing on lessons learned from prevention studies in nononcology populations as well as from the more limited experience in cancer survivors. |
| format | Article |
| id | doaj-art-f056e992899f4b54a79a724c34bf9fb1 |
| institution | OA Journals |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-f056e992899f4b54a79a724c34bf9fb12025-08-20T02:22:05ZengWileyCardiology Research and Practice2090-80162090-05972012-01-01201210.1155/2012/713294713294Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood CancerSaro H. Armenian0Sarah K. Gelehrter1Eric J. Chow2Department of Population Sciences, City of Hope Comprehensive Cancer Center, 1500 East Duarte Bovlevard, Duarte, CA 91010, USADivision of Pediatric Cardiology, Department of Pediatrics and Communicable Diseases, C.S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI 48109, USAClinical Research and Public Health Science Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USACardiovascular complications are a leading cause of therapy-related morbidity and mortality in long-term survivors of childhood malignancy. In fact, childhood cancer survivors are at a 15-fold risk of developing CHF compared to age-matched controls. There is a strong dose-dependent association between anthracycline exposure and risk of CHF, and the incidence increases with longer followup. Outcome following diagnosis of CHF is generally poor, with overall survival less than 50% at 5 years. The growing number of childhood cancer survivors makes it imperative that strategies be developed to prevent symptomatic heart disease in this vulnerable population. We present here an overview of the current state of knowledge regarding primary, secondary, and tertiary prevention strategies for childhood cancer survivors at high risk for CHF, drawing on lessons learned from prevention studies in nononcology populations as well as from the more limited experience in cancer survivors.http://dx.doi.org/10.1155/2012/713294 |
| spellingShingle | Saro H. Armenian Sarah K. Gelehrter Eric J. Chow Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer Cardiology Research and Practice |
| title | Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer |
| title_full | Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer |
| title_fullStr | Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer |
| title_full_unstemmed | Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer |
| title_short | Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer |
| title_sort | strategies to prevent anthracycline related congestive heart failure in survivors of childhood cancer |
| url | http://dx.doi.org/10.1155/2012/713294 |
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