Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017–2020 National Health and Nutrition Examination Survey
Background and objectiveThe Oxidative Balance Score (OBS) has been linked to various chronic diseases; however, its association with gallstone prevalence remains underexplored. This study aimed to investigate the relationship between OBS and gallstone risk.MethodsThis cross-sectional study utilized...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1521882/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832582553681264640 |
|---|---|
| author | Ting Xiong Ting Xiong Ting Xiong Zhonghuo Chen Zhonghuo Chen Zhonghuo Chen Jianwei Yi Jianwei Yi Jianwei Yi Taozhi Yu Taozhi Yu Taozhi Yu Kai Wang Kai Wang Kai Wang Kai Wang |
| author_facet | Ting Xiong Ting Xiong Ting Xiong Zhonghuo Chen Zhonghuo Chen Zhonghuo Chen Jianwei Yi Jianwei Yi Jianwei Yi Taozhi Yu Taozhi Yu Taozhi Yu Kai Wang Kai Wang Kai Wang Kai Wang |
| author_sort | Ting Xiong |
| collection | DOAJ |
| description | Background and objectiveThe Oxidative Balance Score (OBS) has been linked to various chronic diseases; however, its association with gallstone prevalence remains underexplored. This study aimed to investigate the relationship between OBS and gallstone risk.MethodsThis cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2017 to March 2020. Weighted logistic regression models were applied to examine the association between OBS and the prevalence of gallstones, complemented by subgroup and sensitivity analyses. Restricted cubic spline (RCS) was used to investigate the nonlinear association between OBS and the prevalence of gallstones.ResultsA total of 5,382 participants were included, among whom 592 reported a history of gallstones. After adjusting for confounding factors, a significant negative association was observed between OBS and gallstone prevalence (quartile 4 vs. quartile 1: odds ratio [OR] 0.63, 95% confidence interval [CI] 0.43–0.90, p = 0.019). The RCS analysis further supported a negative linear relationship between OBS and gallstone risk (nonlinear p = 0.149). The findings of the subgroup analyses exhibited considerable consistency.ConclusionThis study identified a significant negative linear association between OBS and gallstone risk, suggesting that higher OBS levels are associated with a reduced likelihood of gallstone formation. |
| format | Article |
| id | doaj-art-f04a9c03a1c0483a8a60659e7ee3e3db |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj-art-f04a9c03a1c0483a8a60659e7ee3e3db2025-01-29T15:25:45ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.15218821521882Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017–2020 National Health and Nutrition Examination SurveyTing Xiong0Ting Xiong1Ting Xiong2Zhonghuo Chen3Zhonghuo Chen4Zhonghuo Chen5Jianwei Yi6Jianwei Yi7Jianwei Yi8Taozhi Yu9Taozhi Yu10Taozhi Yu11Kai Wang12Kai Wang13Kai Wang14Kai Wang15Division of Hepato-Biliary-Pancreatic Surgery, Department of General Surgery, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Province Engineering Research Center of Hepatobiliary Disease, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Provincial Key Laboratory of Molecular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDivision of Hepato-Biliary-Pancreatic Surgery, Department of General Surgery, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Province Engineering Research Center of Hepatobiliary Disease, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Provincial Key Laboratory of Molecular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDivision of Hepato-Biliary-Pancreatic Surgery, Department of General Surgery, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Province Engineering Research Center of Hepatobiliary Disease, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Provincial Key Laboratory of Molecular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDivision of Hepato-Biliary-Pancreatic Surgery, Department of General Surgery, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Province Engineering Research Center of Hepatobiliary Disease, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Provincial Key Laboratory of Molecular Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, ChinaDivision of Hepato-Biliary-Pancreatic Surgery, Department of General Surgery, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Province Engineering Research Center of Hepatobiliary Disease, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaThe MOE Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaJiangxi Provincial Clinical Research Center for General Surgery Disease, the Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, ChinaBackground and objectiveThe Oxidative Balance Score (OBS) has been linked to various chronic diseases; however, its association with gallstone prevalence remains underexplored. This study aimed to investigate the relationship between OBS and gallstone risk.MethodsThis cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) conducted from 2017 to March 2020. Weighted logistic regression models were applied to examine the association between OBS and the prevalence of gallstones, complemented by subgroup and sensitivity analyses. Restricted cubic spline (RCS) was used to investigate the nonlinear association between OBS and the prevalence of gallstones.ResultsA total of 5,382 participants were included, among whom 592 reported a history of gallstones. After adjusting for confounding factors, a significant negative association was observed between OBS and gallstone prevalence (quartile 4 vs. quartile 1: odds ratio [OR] 0.63, 95% confidence interval [CI] 0.43–0.90, p = 0.019). The RCS analysis further supported a negative linear relationship between OBS and gallstone risk (nonlinear p = 0.149). The findings of the subgroup analyses exhibited considerable consistency.ConclusionThis study identified a significant negative linear association between OBS and gallstone risk, suggesting that higher OBS levels are associated with a reduced likelihood of gallstone formation.https://www.frontiersin.org/articles/10.3389/fnut.2025.1521882/fulloxidative balance scoregallstoneNHANESretrospective studycross-sectional study |
| spellingShingle | Ting Xiong Ting Xiong Ting Xiong Zhonghuo Chen Zhonghuo Chen Zhonghuo Chen Jianwei Yi Jianwei Yi Jianwei Yi Taozhi Yu Taozhi Yu Taozhi Yu Kai Wang Kai Wang Kai Wang Kai Wang Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017–2020 National Health and Nutrition Examination Survey Frontiers in Nutrition oxidative balance score gallstone NHANES retrospective study cross-sectional study |
| title | Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017–2020 National Health and Nutrition Examination Survey |
| title_full | Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017–2020 National Health and Nutrition Examination Survey |
| title_fullStr | Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017–2020 National Health and Nutrition Examination Survey |
| title_full_unstemmed | Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017–2020 National Health and Nutrition Examination Survey |
| title_short | Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 2017–2020 National Health and Nutrition Examination Survey |
| title_sort | higher levels of oxidative balance score linked to lower risk of gallstones findings from the 2017 2020 national health and nutrition examination survey |
| topic | oxidative balance score gallstone NHANES retrospective study cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1521882/full |
| work_keys_str_mv | AT tingxiong higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT tingxiong higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT tingxiong higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT zhonghuochen higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT zhonghuochen higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT zhonghuochen higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT jianweiyi higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT jianweiyi higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT jianweiyi higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT taozhiyu higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT taozhiyu higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT taozhiyu higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT kaiwang higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT kaiwang higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT kaiwang higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey AT kaiwang higherlevelsofoxidativebalancescorelinkedtolowerriskofgallstonesfindingsfromthe20172020nationalhealthandnutritionexaminationsurvey |