Alterations of the Erythrocyte Membrane during Sepsis
Erythrocytes have been long considered as “dead” cells with transport of oxygen (O2) as their only function. However, the ability of red blood cells (RBCs) to modulate the microcirculation is now recognized as an important additional function. This capacity is regulated by a key element in the rheol...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2012/702956 |
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| author | Yasmina Serroukh Sarah Djebara Christophe Lelubre Karim Zouaoui Boudjeltia Patrick Biston Michael Piagnerelli |
| author_facet | Yasmina Serroukh Sarah Djebara Christophe Lelubre Karim Zouaoui Boudjeltia Patrick Biston Michael Piagnerelli |
| author_sort | Yasmina Serroukh |
| collection | DOAJ |
| description | Erythrocytes have been long considered as “dead” cells with transport of oxygen (O2) as their only function. However, the ability of red blood cells (RBCs) to modulate the microcirculation is now recognized as an important additional function. This capacity is regulated by a key element in the rheologic process: the RBC membrane. This membrane is a complex unit with multiple interactions between the extracellular and intracellular compartments: blood stream, endothelium, and other blood cells on the one hand, and the intracytoplasmic compartment with possible rapid adaptation of erythrocyte metabolism on the other. In this paper, we review the alterations in the erythrocyte membrane observed in critically ill patients and the influence of these alterations on the microcirculatory abnormalities observed in such patients. An understanding of the mechanisms of RBC rheologic alterations in sepsis and their effects on blood flow and on oxygen transport may be important to help reduce morbidity and mortality from severe sepsis. |
| format | Article |
| id | doaj-art-f03f56c71e854ad8a9807af4eae561ff |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-f03f56c71e854ad8a9807af4eae561ff2025-02-03T06:42:02ZengWileyCritical Care Research and Practice2090-13052090-13132012-01-01201210.1155/2012/702956702956Alterations of the Erythrocyte Membrane during SepsisYasmina Serroukh0Sarah Djebara1Christophe Lelubre2Karim Zouaoui Boudjeltia3Patrick Biston4Michael Piagnerelli5Department of Intensive Care, CHU-Charleroi, Université Libre de Bruxelles, 92, Boulevard Janson, 6000 Charleroi, BelgiumDepartment of Intensive Care, CHU-Charleroi, Université Libre de Bruxelles, 92, Boulevard Janson, 6000 Charleroi, BelgiumExperimental Medicine Laboratory, CHU-Charleroi, ULB 222 Unit, 6110 Montigny-le-Tilleul, BelgiumExperimental Medicine Laboratory, CHU-Charleroi, ULB 222 Unit, 6110 Montigny-le-Tilleul, BelgiumDepartment of Intensive Care, CHU-Charleroi, Université Libre de Bruxelles, 92, Boulevard Janson, 6000 Charleroi, BelgiumDepartment of Intensive Care, CHU-Charleroi, Université Libre de Bruxelles, 92, Boulevard Janson, 6000 Charleroi, BelgiumErythrocytes have been long considered as “dead” cells with transport of oxygen (O2) as their only function. However, the ability of red blood cells (RBCs) to modulate the microcirculation is now recognized as an important additional function. This capacity is regulated by a key element in the rheologic process: the RBC membrane. This membrane is a complex unit with multiple interactions between the extracellular and intracellular compartments: blood stream, endothelium, and other blood cells on the one hand, and the intracytoplasmic compartment with possible rapid adaptation of erythrocyte metabolism on the other. In this paper, we review the alterations in the erythrocyte membrane observed in critically ill patients and the influence of these alterations on the microcirculatory abnormalities observed in such patients. An understanding of the mechanisms of RBC rheologic alterations in sepsis and their effects on blood flow and on oxygen transport may be important to help reduce morbidity and mortality from severe sepsis.http://dx.doi.org/10.1155/2012/702956 |
| spellingShingle | Yasmina Serroukh Sarah Djebara Christophe Lelubre Karim Zouaoui Boudjeltia Patrick Biston Michael Piagnerelli Alterations of the Erythrocyte Membrane during Sepsis Critical Care Research and Practice |
| title | Alterations of the Erythrocyte Membrane during Sepsis |
| title_full | Alterations of the Erythrocyte Membrane during Sepsis |
| title_fullStr | Alterations of the Erythrocyte Membrane during Sepsis |
| title_full_unstemmed | Alterations of the Erythrocyte Membrane during Sepsis |
| title_short | Alterations of the Erythrocyte Membrane during Sepsis |
| title_sort | alterations of the erythrocyte membrane during sepsis |
| url | http://dx.doi.org/10.1155/2012/702956 |
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