Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie’s Syndrome
A 40-year-old woman was found to have bilateral Adie’s pupils and generalized muscle stretch areflexia. She did not have orthostatic hypotension but, in an ECG strip in the office, she appeared to have an almost fixed heart rate. We thus studied the heart rate variability (HRV) and the systolic bloo...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/4919758 |
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| author | B. Estañol R. C. Callejas-Rojas S. Cortés R. Martínez-Memije O. Infante-Vázquez G. Delgado-García |
| author_facet | B. Estañol R. C. Callejas-Rojas S. Cortés R. Martínez-Memije O. Infante-Vázquez G. Delgado-García |
| author_sort | B. Estañol |
| collection | DOAJ |
| description | A 40-year-old woman was found to have bilateral Adie’s pupils and generalized muscle stretch areflexia. She did not have orthostatic hypotension but, in an ECG strip in the office, she appeared to have an almost fixed heart rate. We thus studied the heart rate variability (HRV) and the systolic blood pressure variability (SBPV) in supine and standing position and also during rhythmic breathing. We found a decreased HRV in the time domain with very low standard deviation in supine and standing position and during rhythmic breathing. HRV in the frequency domain was low with a decrease in the absolute power of HF and LF and a decrease in the sympathovagal balance in supine and standing positions. SBPV in the time and frequency domains was found to be normal. This patient with Holmes-Adie syndrome had an asymptomatic severe loss of HRV and a preserved SBPV. The global decrease in the HRV in the time and frequency domains indicated that she had both vagal and sympathetic cardiac denervation, whereas the preserved SBPV suggested normal innervation of the blood vessels. |
| format | Article |
| id | doaj-art-f036ad6f42a34e168ce841d261d80b82 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-f036ad6f42a34e168ce841d261d80b822025-02-03T05:45:12ZengWileyCase Reports in Neurological Medicine2090-66682090-66762017-01-01201710.1155/2017/49197584919758Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie’s SyndromeB. Estañol0R. C. Callejas-Rojas1S. Cortés2R. Martínez-Memije3O. Infante-Vázquez4G. Delgado-García5Laboratory of Clinical Neurophysiology, National Institute of Medical Sciences and Nutrition, Mexico City, MexicoLaboratory of Clinical Neurophysiology, National Institute of Medical Sciences and Nutrition, Mexico City, MexicoDepartment of Electromechanical Instrumentation, National Institute of Cardiology, Mexico City, MexicoDepartment of Electromechanical Instrumentation, National Institute of Cardiology, Mexico City, MexicoDepartment of Electromechanical Instrumentation, National Institute of Cardiology, Mexico City, MexicoDepartment of Internal Medicine, University Hospital, Autonomous University of Nuevo León, Monterrey, NL, MexicoA 40-year-old woman was found to have bilateral Adie’s pupils and generalized muscle stretch areflexia. She did not have orthostatic hypotension but, in an ECG strip in the office, she appeared to have an almost fixed heart rate. We thus studied the heart rate variability (HRV) and the systolic blood pressure variability (SBPV) in supine and standing position and also during rhythmic breathing. We found a decreased HRV in the time domain with very low standard deviation in supine and standing position and during rhythmic breathing. HRV in the frequency domain was low with a decrease in the absolute power of HF and LF and a decrease in the sympathovagal balance in supine and standing positions. SBPV in the time and frequency domains was found to be normal. This patient with Holmes-Adie syndrome had an asymptomatic severe loss of HRV and a preserved SBPV. The global decrease in the HRV in the time and frequency domains indicated that she had both vagal and sympathetic cardiac denervation, whereas the preserved SBPV suggested normal innervation of the blood vessels.http://dx.doi.org/10.1155/2017/4919758 |
| spellingShingle | B. Estañol R. C. Callejas-Rojas S. Cortés R. Martínez-Memije O. Infante-Vázquez G. Delgado-García Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie’s Syndrome Case Reports in Neurological Medicine |
| title | Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie’s Syndrome |
| title_full | Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie’s Syndrome |
| title_fullStr | Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie’s Syndrome |
| title_full_unstemmed | Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie’s Syndrome |
| title_short | Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie’s Syndrome |
| title_sort | asymptomatic severe vagal and sympathetic cardiac denervation in holmes adie s syndrome |
| url | http://dx.doi.org/10.1155/2017/4919758 |
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