Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury

Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury

Abstract Objective Therapeutic translation is challenging in spinal cord injury (SCI) and large animal models with high clinical relevance may accelerate therapeutic development. Pigs have important anatomical and physiological similarities to humans. Intraspinal inflammation mediates SCI pathophysi...

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Bibliographic Details
Main Authors: Reena Kumari, Gabrielle V. Hammers, Robert H. Hammons, Andrew N. Stewart, Steven M. MacLean, Tracy Niedzielko, Lonnie E. Schneider, Candace L. Floyd, John C. Gensel
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Neuroinflammation
Subjects:
Gender
Immune
Neurotrauma
Adaptive
Innate
Neuron
Online Access:https://doi.org/10.1186/s12974-025-03338-1
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