Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study
Osteoarthritis (OA) is a disabling disease that causes pain and functional limitation. OA symptoms can be treated with intra-articular injections of anti-inflammatory, viscosupplementary, or viscoinductive products. Non-responders to these approaches have limited options, often surgical (e.g. knee r...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2024-08-01
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| Series: | European Journal of Translational Myology |
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| Online Access: | https://www.pagepressjournals.org/bam/article/view/12413 |
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| author | Nicola Manocchio Concetta Ljoka Nicolò Piacentini Roberto Sorge Giulia Vita Calogero Foti |
| author_facet | Nicola Manocchio Concetta Ljoka Nicolò Piacentini Roberto Sorge Giulia Vita Calogero Foti |
| author_sort | Nicola Manocchio |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a disabling disease that causes pain and functional limitation. OA symptoms can be treated with intra-articular injections of anti-inflammatory, viscosupplementary, or viscoinductive products. Non-responders to these approaches have limited options, often surgical (e.g. knee replacement). This retrospective study aims to evaluate the efficacy of a single injection of Carboxymethyl-Chitosan for advanced (Kellgren-Lawrence ≥3) and symptomatic knee OA in non-responders to hyaluronic acid. We enrolled 10 patients (5 female, 5 male). Treatment efficacy was assessed through the Visual Analogue Scale (VAS, pain) and the Knee Injury and Osteoarthritis Outcome Score (KOOS, knee function). Data are acquired from rating scales were administered at the time of injection (T0), one month (T1), three months (T2), and six months (T3) after treatment as for clinical practice. Results showed a significant improvement in pain and function at T1, with a subsequent gradual resumption of symptoms. In conclusion, the treatment showed a better outcome in the short term (i.e. up to 1 month after treatment); however, raw values of VAS and KOOS did not return to baseline levels showing a maintenance of improvement albeit not statistically significant.
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| format | Article |
| id | doaj-art-f0319686e88d461594221dd0334fb12f |
| institution | Kabale University |
| issn | 2037-7452 2037-7460 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Translational Myology |
| spelling | doaj-art-f0319686e88d461594221dd0334fb12f2025-02-01T10:56:15ZengPAGEPress PublicationsEuropean Journal of Translational Myology2037-74522037-74602024-08-01343Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot studyNicola Manocchio0Concetta Ljoka1Nicolò Piacentini2Roberto Sorge3Giulia Vita4Calogero Foti5Physical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, University of Rome Tor VergataPhysical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, University of Rome Tor Vergata, Italy; Physical and Rehabilitation Medicine Unit, Tor Vergata University Hospital, RomePhysical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, University of Rome Tor VergataSystems Medicine, Biometric Unit, University of Rome Tor VergataPhysical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, University of Rome Tor VergataPhysical and Rehabilitation Medicine, Clinical Sciences and Translational Medicine Department, University of Rome Tor Vergata, Italy; Physical and Rehabilitation Medicine Unit, Tor Vergata University Hospital, RomeOsteoarthritis (OA) is a disabling disease that causes pain and functional limitation. OA symptoms can be treated with intra-articular injections of anti-inflammatory, viscosupplementary, or viscoinductive products. Non-responders to these approaches have limited options, often surgical (e.g. knee replacement). This retrospective study aims to evaluate the efficacy of a single injection of Carboxymethyl-Chitosan for advanced (Kellgren-Lawrence ≥3) and symptomatic knee OA in non-responders to hyaluronic acid. We enrolled 10 patients (5 female, 5 male). Treatment efficacy was assessed through the Visual Analogue Scale (VAS, pain) and the Knee Injury and Osteoarthritis Outcome Score (KOOS, knee function). Data are acquired from rating scales were administered at the time of injection (T0), one month (T1), three months (T2), and six months (T3) after treatment as for clinical practice. Results showed a significant improvement in pain and function at T1, with a subsequent gradual resumption of symptoms. In conclusion, the treatment showed a better outcome in the short term (i.e. up to 1 month after treatment); however, raw values of VAS and KOOS did not return to baseline levels showing a maintenance of improvement albeit not statistically significant. https://www.pagepressjournals.org/bam/article/view/12413Knee osteoarthritisintra-articular injectionsCarboxymethyl-Chitosanhyaluronic acidquality of life |
| spellingShingle | Nicola Manocchio Concetta Ljoka Nicolò Piacentini Roberto Sorge Giulia Vita Calogero Foti Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study European Journal of Translational Myology Knee osteoarthritis intra-articular injections Carboxymethyl-Chitosan hyaluronic acid quality of life |
| title | Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study |
| title_full | Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study |
| title_fullStr | Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study |
| title_full_unstemmed | Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study |
| title_short | Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study |
| title_sort | intra articular injections with carboxymethyl chitosan in patients affected by knee osteoarthritis non responders to hyaluronic acid a pilot study |
| topic | Knee osteoarthritis intra-articular injections Carboxymethyl-Chitosan hyaluronic acid quality of life |
| url | https://www.pagepressjournals.org/bam/article/view/12413 |
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